Hyperbranched mixed-mode anion-exchange polymeric sorbent for highly selective extraction of nine acidic non-steroidal anti-inflammatory drugs from human urine
文献类型：期刊论文
| 作者 | Wang, Longxing1; Chen, Jiping1; Huang, Chaonan1,4; Li, Yun1; Yang, Jiajia3; Peng, Junyu1,4; Tan, Jun2; Fan, Yun1 |
| 刊名 | TALANTA
 |
| 出版日期 | 2018-12-01 |
| 卷号 | 190页码:15-22 |
| 关键词 | Quatemized hyperbranched macromolecules Poly(divinylbenzene) Mixed-mode anion-exchange SPE Acidic NSAIDs Human urine |
| ISSN号 | 0039-9140 |
| DOI | 10.1016/j.talanta.2018.07.033 |
| 通讯作者 | Chen, Jiping(chenjp@dicp.ac.cn) |
| 英文摘要 | This paper describes the poly(divinylbenzene) (PDVB) supported synthesis of quaternized hyperbranched macromolecules (QHMs) and its use as a highly selective, high-capacity mixed-mode anion-exchange (MAX) sorbent. In detail, the aminated PDVB support was firstly synthesized by copolymerization of divinylbenzene and 2-(diethylamino)ethyl methacrylate via Pickering emulsion polymerization. The QHMs were then grafted on PDVB by a divergent synthesis involving consecutive reactions of resorcinol diglycidyl ether with methylamine (N, N-dimethylethanolamine for terminal epoxides), which brought in a high density of quaternary ammonium functionalities. The changes of specific surface area (SBET), pore volume and ion exchange capacity (IEC) with generation number reveal that the QHMs have been grown successfully within the large meso-channels of the porous aminated PDVB. The best compromise between the SBET, pore volume and IEC was obtained at the 4th generation (G4). Due to the highest IEC (0.47 meq/g), the G4-QHMs was successfully applied for mixed-mode solid phase extraction (SPE) of acidic non-steroidal anti-inflammatory drugs (NSAIDs). An efficient approach based on the mixed-mode SPE coupled with HPLC-UV was developed for highly selective extraction and cleanup of nine NSAIDs (tolmetin, TLM; ketoprofen, KEP; naproxen, NAP; flurbiprofen, FLB; diclofenac, DIC; indomethacin, INM; ibuprofen, IBP; mefenamic acid, MFA; tolfenamic acid, TFA) in human urine samples. Under the optimized conditions, the method exhibited satisfactory recoveries ranging from 81.9% to 104.0% with relative standard deviation (RSD) values below 8.5%, good sensitivity (0.004-0.009 mu g mL(-1) limit of detection) and good linearity (coefficient of determination, R-2 > 0.997, 0.01-0.2 mu g mL(-1) for NAP, 0.05-1.0 mu g mL(-1) for FLB, DIC, INM, MFA, TFA, 0.1-2.0 mu g mL(-1) for TLM, KEP, IBP). The hyperbranched MAX sorbent is superior to Oasis HLB and comparable to Oasis MAX in obtaining clean chromatographic profiles. Our results demonstrate the potential application of the hyperbranched MAX for complex sample analysis. |
| WOS关键词 | SOLID-PHASE EXTRACTION ; ENVIRONMENTAL WATER SAMPLES ; TANDEM MASS-SPECTROMETRY ; LIQUID-CHROMATOGRAPHY ; MESOPOROUS SILICA ; WASTE-WATER ; MICROEXTRACTION ; POLYAMIDOAMINE ; ADSORPTION ; PHARMACEUTICALS |
| 资助项目 | Nation Natural Science Foundation of China[21705149] ; Nation Natural Science Foundation of China[21475130] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000445306500003 |
| 出版者 | ELSEVIER SCIENCE BV |
| 资助机构 | Nation Natural Science Foundation of China ; Nation Natural Science Foundation of China ; Nation Natural Science Foundation of China ; Nation Natural Science Foundation of China ; Nation Natural Science Foundation of China ; Nation Natural Science Foundation of China ; Nation Natural Science Foundation of China ; Nation Natural Science Foundation of China |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/167028]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 通讯作者 | Chen, Jiping |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, 457 Zhongshan Rd, Dalian 116023, Peoples R China 2.Hunan Agr Univ, Hunan Engn & Technol Res Ctr Grapes, Changsha, Hunan, Peoples R China 3.Hebei Univ Engn, Coll Mat Sci & Engn, 199 South Guangming St, Handan 056038, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Longxing,Chen, Jiping,Huang, Chaonan,et al. Hyperbranched mixed-mode anion-exchange polymeric sorbent for highly selective extraction of nine acidic non-steroidal anti-inflammatory drugs from human urine[J]. TALANTA,2018,190:15-22. |
| APA | Wang, Longxing.,Chen, Jiping.,Huang, Chaonan.,Li, Yun.,Yang, Jiajia.,...&Fan, Yun.(2018).Hyperbranched mixed-mode anion-exchange polymeric sorbent for highly selective extraction of nine acidic non-steroidal anti-inflammatory drugs from human urine.TALANTA,190,15-22. |
| MLA | Wang, Longxing,et al."Hyperbranched mixed-mode anion-exchange polymeric sorbent for highly selective extraction of nine acidic non-steroidal anti-inflammatory drugs from human urine".TALANTA 190(2018):15-22. |
入库方式： OAI收割
来源：大连化学物理研究所
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