Acute exposure to crotonaldehyde induces dysfunction of immune system in male Wistar rats
文献类型：期刊论文
| 作者 | Wang, Limeng2,3; Yang, Zhihua1; Xu, Long1; Pan, Xiujie1; Liu, Xingyu5; Zhao, Junwei4; Xie, Jianping4; Zhu, Maoxiang1; Li, Xiang4 |
| 刊名 | JOURNAL OF TOXICOLOGICAL SCIENCES
 |
| 出版日期 | 2018 |
| 卷号 | 43期号:1-3页码:33-44 |
| 关键词 | Crotonaldehyde Male Wistar Rats Immune System |
| ISSN号 | 0388-1350 |
| 文献子类 | Article |
| 英文摘要 | Crotonaldehyde is a ubiquitous air pollutant in the environment. It is reported to be harmful to the biosystems in vivo and in vitro. The exposure to crotonaldehyde irritates the mucous membranes and induces edema, hyperemia, cell necrosis, inflammation, and acute respiratory distress syndrome in the lungs. However, the effects of crotonaldehyde on the immune system have not been reported. In the present study, 6-8 weeks old male Wistar rats were exposed to crotonaldehyde by intratracheal instillation at doses of 4, 8, and 16 mu L/kg body weight (b.w.). The general damage in the animals was investigated; the cell counting and the biochemical analysis in the peripheral blood were tested. Furthermore, we investigated the functions of alveolar macrophages (AMs), the alterations of the T-lymphocyte subsets, and the cell composition in the bronchoalveolar lavage fluid (BALF). We found that the activities of the animals were changed after exposure to crotonaldehyde, the cellular ratios and the biochemical components in the peripheral blood were altered, the ratio of mononuclear phagocytes decreased, and the ratios of lymphocytes and granulocytes elevated significantly in BALF. Meanwhile, crotonaldehyde altered the ratio of the T-lymphocyte subsets, and the phagocytic rates and indices of AMs increased obviously. In conclusion, crotonaldehyde induces dysfunction of immune system in male Wistar rats. |
| WOS关键词 | CIGARETTE-SMOKE ; ALPHA,BETA-UNSATURATED ALDEHYDES ; ALVEOLAR MACROPHAGES ; BUTADIENE MONOXIDE ; LIVER MICROSOMES ; 1,3-BUTADIENE ; MICE ; INFLAMMATION ; ACROLEIN ; CELLS |
| WOS研究方向 | Toxicology |
| 语种 | 英语 |
| WOS记录号 | WOS:000430646100005 |
| 出版者 | JAPANESE SOC TOXICOLOGICAL SCIENCES |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/167120]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 通讯作者 | Xie, Jianping |
| 作者单位 | 1.Beijing Inst Radiat Med, Dept Radiat Toxicol & Oncol, 27 Taiping Rd, Beijing 100850, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, 457 Zhongshan Rd, Dalian 116023, Peoples R China 3.Univ Chinese Acad Sci, 19 Yuquan Rd, Beijing 100049, Peoples R China 4.Zhengzhou Tobacco Res Inst CNTC, Key Lab Tobacco Chem, 2 Fengyang Rd, Zhengzhou 450001, Henan, Peoples R China 5.Shanghai Tobacco Grp Corp CNTC, 99 Wansheng South St, Beijing 101121, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Limeng,Yang, Zhihua,Xu, Long,et al. Acute exposure to crotonaldehyde induces dysfunction of immune system in male Wistar rats[J]. JOURNAL OF TOXICOLOGICAL SCIENCES,2018,43(1-3):33-44. |
| APA | Wang, Limeng.,Yang, Zhihua.,Xu, Long.,Pan, Xiujie.,Liu, Xingyu.,...&Li, Xiang.(2018).Acute exposure to crotonaldehyde induces dysfunction of immune system in male Wistar rats.JOURNAL OF TOXICOLOGICAL SCIENCES,43(1-3),33-44. |
| MLA | Wang, Limeng,et al."Acute exposure to crotonaldehyde induces dysfunction of immune system in male Wistar rats".JOURNAL OF TOXICOLOGICAL SCIENCES 43.1-3(2018):33-44. |
入库方式： OAI收割
来源：大连化学物理研究所
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