Facile Preparation of N-Alkyl-2-pyrrolidones in a Continuous-Flow Microreactor
文献类型：期刊论文
| 作者 | Wang, Kejun1,2; Zhou, Feng1,2; Zhang, Boyu1; Liu, Hongchen1,2; Wen, Zhenghui1,2; Chen, Guangwen1 |
| 刊名 | ORGANIC PROCESS RESEARCH & DEVELOPMENT
 |
| 出版日期 | 2018-04-01 |
| 卷号 | 22期号:4页码:504-511 |
| ISSN号 | 1083-6160 |
| DOI | 10.1021/acs.oprd.7b00392 |
| 文献子类 | Article |
| 英文摘要 | N-Alkyl-2-pyrrolidones have been widely used in the petrochemical industry, the agricultural chemical industry, electronic materials, etc. The distinct advantages of using N-alkyl-2-pyrrolidones as solvents or reaction media make them particularly important. A continuous-flow microreactor was exploited for the preparation of N-methyl-2-pyrrolidone (NMP) and N-ethyl-2-pyrrolidone (NEP) in a highly controlled and safe manner; thus, its use improved the efficiency of the process. Various conditions (temperature, residence time, molar ratio of amine to gamma-butyrolactone (GBL), GBL concentration, water content, and presence of H3BO3 catalyst) were investigated to improve the synthesis of NMP/NEP. A microreactor was employed for the conversion of GBL to NMP and NEP, and the yields reached 94.7% for NMP and 93.9% for NEP under the optimized conditions. Furthermore, a kinetic model based on the reaction mechanism was proposed to guide the design and optimization of the synthesis of NMP/NEP. |
| WOS关键词 | PARTIAL OXIDATION ; SCALE-UP ; EFFICIENT ; NITRATION ; REACTOR ; TOLUENE ; ACID |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000430898300007 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/167166]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 通讯作者 | Chen, Guangwen |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian Natl Lab Clean Energy, Dalian 116023, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Kejun,Zhou, Feng,Zhang, Boyu,et al. Facile Preparation of N-Alkyl-2-pyrrolidones in a Continuous-Flow Microreactor[J]. ORGANIC PROCESS RESEARCH & DEVELOPMENT,2018,22(4):504-511. |
| APA | Wang, Kejun,Zhou, Feng,Zhang, Boyu,Liu, Hongchen,Wen, Zhenghui,&Chen, Guangwen.(2018).Facile Preparation of N-Alkyl-2-pyrrolidones in a Continuous-Flow Microreactor.ORGANIC PROCESS RESEARCH & DEVELOPMENT,22(4),504-511. |
| MLA | Wang, Kejun,et al."Facile Preparation of N-Alkyl-2-pyrrolidones in a Continuous-Flow Microreactor".ORGANIC PROCESS RESEARCH & DEVELOPMENT 22.4(2018):504-511. |
入库方式： OAI收割
来源：大连化学物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。