Direct Detection of Small & IT;n & IT;-Alkanes at Sub-ppbv Level by Photoelectron-Induced O-2(+) Cation Chemical Ionization Mass Spectrometry at kPa Pressure
文献类型：期刊论文
| 作者 | Jiang, Jichun2; Wu, Chenxin1,2; Li, Haiyang2; Wang, Yan1,2; Hua, Lei2; Li, Qingyun3; Hou, Keyong2 |
| 刊名 | ANALYTICAL CHEMISTRY
 |
| 出版日期 | 2018-04-17 |
| 卷号 | 90期号:8页码:5398-5404 |
| ISSN号 | 0003-2700 |
| DOI | 10.1021/acs.analchem.8b00595 |
| 文献子类 | Article |
| 英文摘要 | Direct mass spectrometric measurements of saturated hydrocarbons, especially small n-alkanes, remains a great challenge because of low basicity and lack of ionizable functional groups. In this work, a novel high-pressure photoelectron-induced O-2(+) cation chemical ionization source (HPPI-OCI) at kPa based on a 10.6 eV krypton lamp was developed for a time-of-flight mass spectrometer (TOFMS). High-intensity O-2(+) reactant ions were generated by photo-electron ionization of air molecules in the double electric field ionization region. The quasi-molecular ions, [M-H](+), of C3-C6 n-alkanes, gradually dominated in the mass spectra when the ion source pressure was elevated from 88 to 1080 Pa, with more than 3 orders of magnitude improvement in signal intensity. As a result, the achieved limits of detection were lowered to 0.14, 0.11, 0.07, and 0.1 ppbv for propane, n-butane, n-pentane, and n-hexane, respectively. The performance of the HPPI-OCI TOFMS was first demonstrated by analysis of exhaled small n-alkanes from healthy smokers and nonsmokers. Then the concentration variations of exhaled small n-alkanes of four healthy volunteers were analyzed after alcohol consumption to explore the alcohol-hepatoxicity-related oxidative stress. In summary, this work provides new insights for controlling the O-2(+)-participating chemical ionization by adjusting the ion source pressure and develops a novel direct mass spectrometric method for sensitive measurements of mall n-alkanes. |
| WOS关键词 | SINGLE-PHOTON IONIZATION ; ATOMIC GOLD CATIONS ; ION FLOW TUBE ; OXIDATIVE STRESS ; BREATH ANALYSIS ; ATMOSPHERIC-PRESSURE ; LIPID-PEROXIDATION ; CROSS-SECTIONS ; EXHALED BREATH ; LINEAR ALKANES |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| WOS记录号 | WOS:000430512200063 |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/167212]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 通讯作者 | Li, Haiyang; Hua, Lei |
| 作者单位 | 1.Univ Chinese Acad Sci, 19 Yuquan Rd, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, 457 Zhongshan Rd, Dalian 116023, Liaoning, Peoples R China 3.Jilin Univ, Coll Instrumentat & Elect Engn, Changchun 130061, Jilin, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jiang, Jichun,Wu, Chenxin,Li, Haiyang,et al. Direct Detection of Small & IT;n & IT;-Alkanes at Sub-ppbv Level by Photoelectron-Induced O-2(+) Cation Chemical Ionization Mass Spectrometry at kPa Pressure[J]. ANALYTICAL CHEMISTRY,2018,90(8):5398-5404. |
| APA | Jiang, Jichun.,Wu, Chenxin.,Li, Haiyang.,Wang, Yan.,Hua, Lei.,...&Hou, Keyong.(2018).Direct Detection of Small & IT;n & IT;-Alkanes at Sub-ppbv Level by Photoelectron-Induced O-2(+) Cation Chemical Ionization Mass Spectrometry at kPa Pressure.ANALYTICAL CHEMISTRY,90(8),5398-5404. |
| MLA | Jiang, Jichun,et al."Direct Detection of Small & IT;n & IT;-Alkanes at Sub-ppbv Level by Photoelectron-Induced O-2(+) Cation Chemical Ionization Mass Spectrometry at kPa Pressure".ANALYTICAL CHEMISTRY 90.8(2018):5398-5404. |
入库方式： OAI收割
来源：大连化学物理研究所
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