Formation and recognition of G-quadruplex relevant for pilin antigenic variation in Neisseria gonorrhoeae
文献类型：期刊论文
| 作者 | He, Xiangwei; Zhang, Zhenjiang; Yuan, Gu |
| 刊名 | CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE
 |
| 出版日期 | 2012 |
| 卷号 | 90期号:1页码:34-38 |
| 关键词 | Formation Recognition G-quadruplex Pilin Antigenic Variation Neisseria Gonorrhoeae |
| ISSN号 | 0008-4042 |
| DOI | 10.1139/V11-092 |
| 文献子类 | Article |
| 英文摘要 | In this research, NMR, ESI-MS, and circular dichroism (CD) spectroscopies were used to investigate the formation and recognition of G-quadruplex by a G-rich sequence that has been demonstrated to be relevant for pilin variation in Neisseria gonorrhoeae. The NMR spectra provided strong evidence that the G-quadruplex structure was formed from this G-rich sequence, and this result was confirmed by CD spectroscopy. In addition, two small-molecule natural products (jatrorrhizine hydrochloride (J) and dehydrocorydaline (D)) were found to bind to this G-quadruplex over the corresponding duplex DNA with high selectivity by ESI-MS. |
| WOS关键词 | TELOMERIC G-QUADRUPLEX ; THERAPEUTIC TARGETS ; PROMOTER REGION ; CONVERSION ; ONCOGENE |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000299578600004 |
| 出版者 | CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/167232]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 通讯作者 | Yuan, Gu |
| 作者单位 | Peking Univ, Beijing Natl Lab Mol Sci, Key Lab Bioorgan Chem & Mol Engn, Minist Educ,Dept Chem Biol,Coll Chem & Mol Engn, Beijing 100871, Peoples R China |
| 推荐引用方式 GB/T 7714 | He, Xiangwei,Zhang, Zhenjiang,Yuan, Gu. Formation and recognition of G-quadruplex relevant for pilin antigenic variation in Neisseria gonorrhoeae[J]. CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE,2012,90(1):34-38. |
| APA | He, Xiangwei,Zhang, Zhenjiang,&Yuan, Gu.(2012).Formation and recognition of G-quadruplex relevant for pilin antigenic variation in Neisseria gonorrhoeae.CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE,90(1),34-38. |
| MLA | He, Xiangwei,et al."Formation and recognition of G-quadruplex relevant for pilin antigenic variation in Neisseria gonorrhoeae".CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE 90.1(2012):34-38. |
入库方式： OAI收割
来源：大连化学物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。