Anetodermic Pilomatricoma: Molecular Characteristics and Trauma in the Development of Its Bullous Appearance
文献类型：期刊论文
| 作者 | Xiao, Yu3; Li, Li2; Zeng, Yueping2; Fang, Kai2; Jin, Hongzhong2; Ray, Heather1,5,6; Chen, Jiang1,5 |
| 刊名 | AMERICAN JOURNAL OF DERMATOPATHOLOGY
 |
| 出版日期 | 2012-06-01 |
| 卷号 | 34期号:4页码:E41-E45 |
| 关键词 | Pilomatricoma Hair Follicle Tumor Bullous Anetodermic |
| ISSN号 | 0193-1091 |
| DOI | 10.1097/DAD.0b013e31823583f5 |
| 文献子类 | Article |
| 英文摘要 | Pilomatricoma is a common benign neoplasm of the skin characterized by a solid cutaneous nodule of hair matrix origin. The anetodermal or lymphangiectatic variant of pilomatricoma is rare, and its bullous appearance is often associated with attenuated collagen and elastic fibrils and dilated lymphatic vessels in the overlying dermis. However, the tumors of anetodermic pilomatricoma have never been characterized at the molecular level, and the exact mechanism for their development is unknown. In this study, we evaluated histological and molecular features of a bullous pilomatricoma along with 5 control tumors and determined that tumors of both anetodermic and control pilomatricoma comprise similar molecular features, such as nuclear lymphoid enhancer binding factor 1 (LEF1) localization and the expression of keratins. In addition, we associated the development of the anetodermic pilomatricoma with mechanical trauma, scar tissue formation, and increased numbers of blood and lymphatic vessels. This study suggests that the development of the anetodermic form of pilomatricoma is unlikely to be associated with the intrinsic properties of the tumor but with the mechanical trauma that disrupts the dermal integrity and vascular microenvironment. |
| WOS关键词 | BETA-CATENIN ; MORPHOGENESIS ; MUTATIONS ; KERATINS ; TUMORS ; SKIN |
| WOS研究方向 | Dermatology |
| 语种 | 英语 |
| WOS记录号 | WOS:000304452100001 |
| 出版者 | LIPPINCOTT WILLIAMS & WILKINS |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/167236]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 通讯作者 | Chen, Jiang |
| 作者单位 | 1.Univ Colorado, Charles C Gates Ctr Regenerat Med & Stem Cell Bio, Aurora, CO 80045 USA 2.Chinese Acad Sci, Dept Dermatol, Peking Union Med Coll Hosp, Beijing, Peoples R China 3.Chinese Acad Sci, Dept Pathol, Peking Union Med Coll Hosp, Beijing, Peoples R China 4.Peking Union Med Coll, Beijing 100021, Peoples R China 5.Univ Colorado, Dept Dermatol, Aurora, CO 80045 USA 6.Univ Colorado, Program Biomed Sci, Aurora, CO 80045 USA |
| 推荐引用方式 GB/T 7714 | Xiao, Yu,Li, Li,Zeng, Yueping,et al. Anetodermic Pilomatricoma: Molecular Characteristics and Trauma in the Development of Its Bullous Appearance[J]. AMERICAN JOURNAL OF DERMATOPATHOLOGY,2012,34(4):E41-E45. |
| APA | Xiao, Yu.,Li, Li.,Zeng, Yueping.,Fang, Kai.,Jin, Hongzhong.,...&Chen, Jiang.(2012).Anetodermic Pilomatricoma: Molecular Characteristics and Trauma in the Development of Its Bullous Appearance.AMERICAN JOURNAL OF DERMATOPATHOLOGY,34(4),E41-E45. |
| MLA | Xiao, Yu,et al."Anetodermic Pilomatricoma: Molecular Characteristics and Trauma in the Development of Its Bullous Appearance".AMERICAN JOURNAL OF DERMATOPATHOLOGY 34.4(2012):E41-E45. |
入库方式： OAI收割
来源：大连化学物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。