Convenient Method for the Synthesis of a Flexible Cyclic Polyamide for Selective Targeting of c-myb G-quadruplex DNA
文献类型：期刊论文
| 作者 | Zhang, Qiang; Cui, Xiaojie; Lin, Sen; Zhou, Jiang; Yuan, Gu |
| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2012-12-21 |
| 卷号 | 14期号:24页码:6126-6129 |
| ISSN号 | 1523-7060 |
| DOI | 10.1021/ol302918f |
| 文献子类 | Article |
| 英文摘要 | A convenient efficient method for synthesis of a flexible cyclic polyamide (c beta, 1) was developed through cyclodimerization. Electrospray ionization mass spectrometry and nuclear magnetic resonance results showed that 1 selectively binds to the c-myb G-quadruplex with high affinity, and there was no binding with the ILPR, bcl-2, and c-kit G-quadruplexes. This is the first time that a flexible cyclic polyamide was found to have high selectivity for the c-myb G-quadruplex. |
| WOS关键词 | IONIZATION MASS-SPECTROMETRY ; TRIPLET REPEAT DNA ; TELOMERIC DNA ; RECOGNITION ; EXPRESSION ; ONCOGENE ; PROMOTER ; BINDING ; STABILIZATION ; TELOMESTATIN |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| WOS记录号 | WOS:000312564500003 |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/167240]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 通讯作者 | Yuan, Gu |
| 作者单位 | Peking Univ, Beijing Natl Lab Mol Sci, Key Lab Bioorgan Chem & Mol Engn, Minist Educ,Dept Chem Biol,Coll Chem & Mol Engn, Beijing 100871, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Qiang,Cui, Xiaojie,Lin, Sen,et al. Convenient Method for the Synthesis of a Flexible Cyclic Polyamide for Selective Targeting of c-myb G-quadruplex DNA[J]. ORGANIC LETTERS,2012,14(24):6126-6129. |
| APA | Zhang, Qiang,Cui, Xiaojie,Lin, Sen,Zhou, Jiang,&Yuan, Gu.(2012).Convenient Method for the Synthesis of a Flexible Cyclic Polyamide for Selective Targeting of c-myb G-quadruplex DNA.ORGANIC LETTERS,14(24),6126-6129. |
| MLA | Zhang, Qiang,et al."Convenient Method for the Synthesis of a Flexible Cyclic Polyamide for Selective Targeting of c-myb G-quadruplex DNA".ORGANIC LETTERS 14.24(2012):6126-6129. |
入库方式： OAI收割
来源：大连化学物理研究所
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