Membrane-Based Continuous Remover of Trifluoroacetic Acid in Mobile Phase for LC-ESI-MS Analysis of Small Molecules and Proteins
文献类型：期刊论文
| 作者 | Bai, Yu; Liao, Yiping; Zhang, Jialing; Xing, Jiawei; Zhou, Zhigui; Liu, Huwei |
| 刊名 | JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
 |
| 出版日期 | 2012-07-01 |
| 卷号 | 23期号:7页码:1289-1292 |
| 关键词 | Membrane Remover Trifluoroacetic Acid Liquid Chromatography Mass Spectrometry |
| ISSN号 | 1044-0305 |
| DOI | 10.1007/s13361-012-0385-z |
| 文献子类 | Article |
| 英文摘要 | We developed a "continuous" trifluoroacetic acid (TFA) remover based on electrodialysis with bipolar membrane for online coupling of liquid chromatography (LC) and electrospray ionization mass spectrometry (ESI-MS) using TFA containing mobile phase. With the TFA remover as an interface, the TFA anion in the mobile phase was removed based on electrodialysis mechanism, and meanwhile, the anion exchange membrane was self-regenerated by the hydroxide ions produced by the bipolar membrane. So the remover could continuously work without any additional regeneration process. The established LC-TFA remover-MS system has been successfully applied for the qualitative and quantitative analysis of small molecules as well as proteins. |
| WOS关键词 | IONIZATION MASS-SPECTROMETRY ; ELECTROSPRAY-IONIZATION ; SIGNAL ENHANCEMENT ; BIPOLAR MEMBRANES ; SENSITIVITY |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry ; Spectroscopy |
| 语种 | 英语 |
| WOS记录号 | WOS:000305231700016 |
| 出版者 | SPRINGER |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/167278]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 通讯作者 | Liu, Huwei |
| 作者单位 | Peking Univ, Beijing Natl Lab Mol Sci, Key Lab Bioorgan Chem & Mol Engn, Minist Educ,Inst Analyt Chem,Coll Chem & Mol Engn, Beijing 100871, Peoples R China |
| 推荐引用方式 GB/T 7714 | Bai, Yu,Liao, Yiping,Zhang, Jialing,et al. Membrane-Based Continuous Remover of Trifluoroacetic Acid in Mobile Phase for LC-ESI-MS Analysis of Small Molecules and Proteins[J]. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY,2012,23(7):1289-1292. |
| APA | Bai, Yu,Liao, Yiping,Zhang, Jialing,Xing, Jiawei,Zhou, Zhigui,&Liu, Huwei.(2012).Membrane-Based Continuous Remover of Trifluoroacetic Acid in Mobile Phase for LC-ESI-MS Analysis of Small Molecules and Proteins.JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY,23(7),1289-1292. |
| MLA | Bai, Yu,et al."Membrane-Based Continuous Remover of Trifluoroacetic Acid in Mobile Phase for LC-ESI-MS Analysis of Small Molecules and Proteins".JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY 23.7(2012):1289-1292. |
入库方式： OAI收割
来源：大连化学物理研究所
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