Selective recognition of G-quadruplex in the vascular endothelial growth factor gene with small-molecule natural products by electrospray ionization (ESI) mass spectrometry and circular dichroism (CD) spectrometry
文献类型：期刊论文
| 作者 | He, Xiangwei; Zhang, Zhenjiang; Zhang, Qiang; Yuan, Gu |
| 刊名 | CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE
 |
| 出版日期 | 2012 |
| 卷号 | 90期号:1页码:55-59 |
| 关键词 | Vegf Gene Natural Products Dna Recognition Esi Mass Spectrometry Cd Spectroscopy |
| ISSN号 | 0008-4042 |
| DOI | 10.1139/V11-104 |
| 文献子类 | Article |
| 英文摘要 | In this study, electrospray ionization mass spectrometry (ESI-MS) and circular dichroism (CD) spectroscopy were used to investigate selective recognition of G-quadruplex in the vascular endothelial growth factor (VEGF) gene with 12 small-molecule natural products. We found that kaempferol, a natural flavonol, shows the highest binding affinity among the 12 natural molecules. The results from ESI-MS and CD spectra indicated that kaempferol could enhance the thermal stability of the VEGF G-quadruplex and showed selective recognition for the G-quadruplex in a solution consisting of the G-quadruplex and the corresponding duplex DNA. |
| WOS关键词 | PROXIMAL PROMOTER REGION ; INTERACTIVE AGENTS ; TUMOR-CELLS ; DNA ; BINDING ; IDENTIFICATION ; DERIVATIVES ; AFFINITY ; LIGAND ; MOTIF |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000299578600007 |
| 出版者 | CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/167284]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 通讯作者 | Yuan, Gu |
| 作者单位 | Peking Univ, Beijing Natl Lab Mol Sci, Key Lab Bioorgan Chem & Mol Engn, Minist Educ,Dept Chem Biol,Coll Chem, Beijing 100871, Peoples R China |
| 推荐引用方式 GB/T 7714 | He, Xiangwei,Zhang, Zhenjiang,Zhang, Qiang,et al. Selective recognition of G-quadruplex in the vascular endothelial growth factor gene with small-molecule natural products by electrospray ionization (ESI) mass spectrometry and circular dichroism (CD) spectrometry[J]. CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE,2012,90(1):55-59. |
| APA | He, Xiangwei,Zhang, Zhenjiang,Zhang, Qiang,&Yuan, Gu.(2012).Selective recognition of G-quadruplex in the vascular endothelial growth factor gene with small-molecule natural products by electrospray ionization (ESI) mass spectrometry and circular dichroism (CD) spectrometry.CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE,90(1),55-59. |
| MLA | He, Xiangwei,et al."Selective recognition of G-quadruplex in the vascular endothelial growth factor gene with small-molecule natural products by electrospray ionization (ESI) mass spectrometry and circular dichroism (CD) spectrometry".CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE 90.1(2012):55-59. |
入库方式： OAI收割
来源：大连化学物理研究所
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