Lipidomics Reveals Mitochondrial Membrane Remodeling Associated with Acute Thermoregulation in a Rodent with a Wide Thermoneutral Zone
文献类型：期刊论文
| 作者 | Pan, Qian2,3; Li, Min1; Shi, Yao-Long2,3; Liu, Huwei1; Speakman, John R.4,5; Wang, De-Hua2 |
| 刊名 | LIPIDS
 |
| 出版日期 | 2014-07-01 |
| 卷号 | 49期号:7页码:715-730 |
| 关键词 | Hplc-esi-ms Lipidomics Mongolian Gerbils Acute Thermoregulation Mitochondrial Membrane Lipid Thermoneutral Zone |
| ISSN号 | 0024-4201 |
| DOI | 10.1007/s11745-014-3900-0 |
| 文献子类 | Article |
| 英文摘要 | Mongolian gerbils (Meriones unguiculatus) have high physiological flexibility in response to acute temperature changes, and have the widest thermoneutral zone (TNZ, 26.5-38.9 A degrees C) reported among small mammals. At the upper critical temperature (T (uc), 38.9 A degrees C), body temperatures of gerbils were significantly increased (39-41 A degrees C) while metabolic rates were maintained at the basal level. In contrast, below the lower critical temperature (T (lc), 26.5 A degrees C), metabolism was elevated and body temperature stable. Rapid changes in mitochondrial membrane lipidome were hypothesized to play an important role during acute thermoregulation of gerbils. Taking advantage of a recent lipidomic technique, we examined changes in the membrane phospholipids environment and free fatty acids (FFA) production in mitochondria between 38 and 27 A degrees C (in the TNZ), and between 27 and 16 A degrees C (below the TNZ). At 38 A degrees C, acute heat stress elicited distinct remodeling in mitochondrial membrane lipidome which related to a potential decrease in mitochondrial respiration and membrane fluidity compared to 27 A degrees C. At 16 A degrees C, a sharply decreased unsaturation index and increased chain lengths were detected in mitochondrial FFA production both in muscle and brown adipose tissue. Our results suggest that mitochondrial membrane lipid remodeling may stabilize membrane function and activity of respiration related membrane protein to maintain a stable metabolic rate at T (uc), and improve heat production by decomposing less fluid fatty acid conjugates of membrane lipids under acute cold exposure. These data therefore imply an important role of membrane remodeling during acute thermoregulation in a non-hibernating endotherm. |
| WOS关键词 | MERIONES-UNGUICULATUS ; BRANDTS VOLES ; FATTY-ACIDS ; INDIRECT CALORIMETRY ; METABOLIC-RATES ; SMALL MAMMALS ; MICE ; LIPIDS ; LIVER ; THERMOGENESIS |
| WOS研究方向 | Biochemistry & Molecular Biology ; Nutrition & Dietetics |
| 语种 | 英语 |
| WOS记录号 | WOS:000338317200010 |
| 出版者 | SPRINGER HEIDELBERG |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/167292]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 通讯作者 | Wang, De-Hua |
| 作者单位 | 1.Peking Univ, Key Lab Bioorgan Chem & Mol Engn, Beijing Natl Lab Mol Sci, Minist Educ,Inst Analyt Chem,Coll Chem & Mol Engn, Beijing 100871, Peoples R China 2.Chinese Acad Sci, Inst Zool, State Key Lab Integrated Management Pest Insects, Beijing 100101, Peoples R China 3.Univ Chinese Acad Sci, Beijing, Peoples R China 4.Chinese Acad Sci, Inst Genet & Dev Biol, Beijing 100101, Peoples R China 5.Univ Aberdeen, Inst Biol & Environm Sci, Aberdeen, Scotland |
| 推荐引用方式 GB/T 7714 | Pan, Qian,Li, Min,Shi, Yao-Long,et al. Lipidomics Reveals Mitochondrial Membrane Remodeling Associated with Acute Thermoregulation in a Rodent with a Wide Thermoneutral Zone[J]. LIPIDS,2014,49(7):715-730. |
| APA | Pan, Qian,Li, Min,Shi, Yao-Long,Liu, Huwei,Speakman, John R.,&Wang, De-Hua.(2014).Lipidomics Reveals Mitochondrial Membrane Remodeling Associated with Acute Thermoregulation in a Rodent with a Wide Thermoneutral Zone.LIPIDS,49(7),715-730. |
| MLA | Pan, Qian,et al."Lipidomics Reveals Mitochondrial Membrane Remodeling Associated with Acute Thermoregulation in a Rodent with a Wide Thermoneutral Zone".LIPIDS 49.7(2014):715-730. |
入库方式： OAI收割
来源：大连化学物理研究所
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