Photoredox-Catalyzed C-H Arylation of Internal Alkenes to Tetrasubstituted Alkenes: Synthesis of Tamoxifen
文献类型：期刊论文
| 作者 | Wang, Quannan2,3; Yang, Xiaoge2; Wu, Ping2,3; Yu, Zhengkun1,2 |
| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2017-11-17 |
| 卷号 | 19期号:22页码:6248-6251 |
| ISSN号 | 1523-7060 |
| DOI | 10.1021/acs.orglett.7b03223 |
| 文献子类 | Article |
| 英文摘要 | Visible-light-induced direct C-H arylation of S,S-functionalized internal alkenes, that is, alpha-oxo ketene dithioacetals and analogues, has been efficiently realized with aryldiazonium salts (ArN2BF4) as coupling partners and Ru(bpy)(3)Cl-2 center dot 6H(2)O as photosensitizer at ambient temperature. The strategy to activate the internal olefinic C-H bond by both the alkylthio and electron-withdrawing functional groups was investigated. The synthetic protocol was successfully applied to the synthesis of all-carbon tetrasubstituted alkenes including tamoxifen. |
| WOS关键词 | DIVERSITY-ORIENTED SYNTHESIS ; OXO KETENE DITHIOACETALS ; CROSS-COUPLING REACTIONS ; STEREOSELECTIVE-SYNTHESIS ; MULTISUBSTITUTED OLEFINS ; EFFICIENT SYNTHESIS ; BOND ACTIVATION ; TRI ; FUNCTIONALIZATION ; ALKENYLATION |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000416204300055 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/168344]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 通讯作者 | Yu, Zhengkun |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, 354 Fenglin Rd, Shanghai 200032, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, 457 Zhongshan Rd, Dalian 116023, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Quannan,Yang, Xiaoge,Wu, Ping,et al. Photoredox-Catalyzed C-H Arylation of Internal Alkenes to Tetrasubstituted Alkenes: Synthesis of Tamoxifen[J]. ORGANIC LETTERS,2017,19(22):6248-6251. |
| APA | Wang, Quannan,Yang, Xiaoge,Wu, Ping,&Yu, Zhengkun.(2017).Photoredox-Catalyzed C-H Arylation of Internal Alkenes to Tetrasubstituted Alkenes: Synthesis of Tamoxifen.ORGANIC LETTERS,19(22),6248-6251. |
| MLA | Wang, Quannan,et al."Photoredox-Catalyzed C-H Arylation of Internal Alkenes to Tetrasubstituted Alkenes: Synthesis of Tamoxifen".ORGANIC LETTERS 19.22(2017):6248-6251. |
入库方式： OAI收割
来源：大连化学物理研究所
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