Process Development and Scale-up of the Continuous Flow Nitration of Trifluoromethoxybenzene
文献类型：期刊论文
| 作者 | Wen, Zhenghui1,2; Jiao, Fengjun1; Yang, Mei1; Zhao, Shuainan1,2; Zhou, Feng1,2; Chen, Guangwen1 |
| 刊名 | ORGANIC PROCESS RESEARCH & DEVELOPMENT
 |
| 出版日期 | 2017-11-01 |
| 卷号 | 21期号:11页码:1843-1850 |
| ISSN号 | 1083-6160 |
| DOI | 10.1021/acs.oprd.7b00291 |
| 文献子类 | Article |
| 英文摘要 | In this work, continuous flow nitration of trifluoromethoxybenzene-(TFMB) was conducted in a microchannel reactor. The effects of process parameters, including temperature, residence tine, sulfuric acid strength, flow rate, and reactor structure, were systemically investigated. It was found that the aforementioned process parameters had significant effect on TFMB conversion, while the product selectivity was merely sensitive to the reaction temperature. On the basis of the results of process parameter optimization, a scale-up strategy combining microreactor with distributed packed tubular reactor was presented. Consequently, excellent performance was achieved in the combined. reactor with a kilogram-scale production. |
| WOS关键词 | MASS-TRANSFER ; NITRIC-ACID ; MICROCHANNEL REACTOR ; PROCESS WINDOWS ; HIGH-OUTPUT ; CHEMISTRY ; MICROREACTOR ; SAFE ; TECHNOLOGY ; SYSTEMS |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000416204700017 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/168358]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 通讯作者 | Chen, Guangwen |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian Natl Lab Clean Energy, Dalian 116023, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wen, Zhenghui,Jiao, Fengjun,Yang, Mei,et al. Process Development and Scale-up of the Continuous Flow Nitration of Trifluoromethoxybenzene[J]. ORGANIC PROCESS RESEARCH & DEVELOPMENT,2017,21(11):1843-1850. |
| APA | Wen, Zhenghui,Jiao, Fengjun,Yang, Mei,Zhao, Shuainan,Zhou, Feng,&Chen, Guangwen.(2017).Process Development and Scale-up of the Continuous Flow Nitration of Trifluoromethoxybenzene.ORGANIC PROCESS RESEARCH & DEVELOPMENT,21(11),1843-1850. |
| MLA | Wen, Zhenghui,et al."Process Development and Scale-up of the Continuous Flow Nitration of Trifluoromethoxybenzene".ORGANIC PROCESS RESEARCH & DEVELOPMENT 21.11(2017):1843-1850. |
入库方式： OAI收割
来源：大连化学物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。