DISTINGUISHING INTRACEREBRAL HEMORRHAGE FROM ACUTE CEREBRAL INFARCTION THROUGH METABOLOMICS
文献类型：期刊论文
| 作者 | Zhang, Xuxin3; Li, Yanzhao3; Liang, Yan3; Sun, Pitong3; Wu, Xue2,4; Song, Jinhui3; Sun, Xiaoyu2,4; Hong, Mo2,4; Gao, Peng1,2,5; Deng, Dongfeng3 |
| 刊名 | REVISTA DE INVESTIGACION CLINICA-CLINICAL AND TRANSLATIONAL INVESTIGATION
 |
| 出版日期 | 2017-11-01 |
| 卷号 | 69期号:6页码:319-328 |
| 关键词 | Acute Cerebral Infarction Artificial Neural Network Intracerebral Hemorrhage Mass Spectrometry Metabolomics |
| ISSN号 | 2385-3956 |
| DOI | 10.24875/RIC.17002348 |
| 文献子类 | Article |
| 英文摘要 | Background: Acute cerebral infarction (ACI) and intracerebral hemorrhage (ICH) are potentially lethal cerebrovascular diseases that seriously impact public health. ACI and ICH share several common clinical manifestations but have totally divergent therapeutic strategies. A poor diagnosis can affect stroke treatment. Objective: To screen for biomarkers to differentiate ICH from ACI, we enrolled 129 ACI and 128 ICH patients and 65 healthy individuals as controls. Methods: Patients with stroke were diagnosed by computed tomography/magnetic resonance imaging, and their blood samples were obtained by fingertip puncture within 2-12 h after stroke initiation. We compared changes in metabolites between ACI and ICH using dried blood spot-based direct infusion mass spectrometry technology for differentiating ICH from ACI. Results: Through multivariate statistical approaches, 11 biomarkers including 3-hydroxylbutyrylcarnitine, glutarylcarnitine (C5DC), myristoylcarnitine, 3-hydroxypalmitoylcarnitine, tyrosine/citrulline (Cit), valine/phenylalanine, C5DC/3-hydroxyisovalerylcarnitine, CSDC/palmitoylcarnitine, hydroxystearoylcarnitine, ratio of sum of CO, C2, C3, C16, and C18:1 to Cit, and propionylcarnitine/methionine were screened. An artificial neural network model was constructed based on these parameters. A training set was evaluated by cross-validation method. The accuracy of this model was checked by an external test set showing a sensitivity of 0.8400 (95% confidence interval [CIL 0.7394-0.9406) and specificity of 0.7692 (95% CI, 0.6536-0.8848). Conclusion: This study confirmed that metabolomic analysis is a promising tool for rapid and timely stroke differentiation and prediction based on differential metabolites. |
| WOS关键词 | ACUTE ISCHEMIC-STROKE ; AMINO-ACID SIGNATURE ; RISK-FACTORS ; METABOLISM ; DISCOVERY ; DISEASE |
| WOS研究方向 | General & Internal Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:000419750200004 |
| 出版者 | INST NACIONAL NUTRICION |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/168530]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 通讯作者 | Zhang, Xuxin; Deng, Dongfeng |
| 作者单位 | 1.Dalian Univ, Affiliated Zhongshan Hosp, Dept SICU, Dalian, Liaoning, Peoples R China 2.Liaoning Med Univ, Affiliated Hosp 1, KLLTCM, Jinzhou, Liaoning, Peoples R China 3.Dalian Univ, Affiliated Zhongshan Hosp, Dept Neurosurg, Dalian, Liaoning, Peoples R China 4.RSKT Biopharma Inc, Jinzhou 121000, Liaoning, Peoples R China 5.Dalian Inst Chem Phys, Chinese Acad Sci, Dept Biotechnol, Dalian, Liaoning, Peoples R China 6.Dalian Sixth Peoples Hosp, Med Ctr, Dept Translat, Clin Lab, Dalian, Liaoning, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Xuxin,Li, Yanzhao,Liang, Yan,et al. DISTINGUISHING INTRACEREBRAL HEMORRHAGE FROM ACUTE CEREBRAL INFARCTION THROUGH METABOLOMICS[J]. REVISTA DE INVESTIGACION CLINICA-CLINICAL AND TRANSLATIONAL INVESTIGATION,2017,69(6):319-328. |
| APA | Zhang, Xuxin.,Li, Yanzhao.,Liang, Yan.,Sun, Pitong.,Wu, Xue.,...&Deng, Dongfeng.(2017).DISTINGUISHING INTRACEREBRAL HEMORRHAGE FROM ACUTE CEREBRAL INFARCTION THROUGH METABOLOMICS.REVISTA DE INVESTIGACION CLINICA-CLINICAL AND TRANSLATIONAL INVESTIGATION,69(6),319-328. |
| MLA | Zhang, Xuxin,et al."DISTINGUISHING INTRACEREBRAL HEMORRHAGE FROM ACUTE CEREBRAL INFARCTION THROUGH METABOLOMICS".REVISTA DE INVESTIGACION CLINICA-CLINICAL AND TRANSLATIONAL INVESTIGATION 69.6(2017):319-328. |
入库方式： OAI收割
来源：大连化学物理研究所
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