Global Metabolic Profiling Identifies a Pivotal Role of Proline and Hydroxyproline Metabolism in Supporting Hypoxic Response in Hepatocellular Carcinoma
文献类型：期刊论文
| 作者 | Tang, Ling2,3,4; Zeng, Jun3,5; Geng, Pengyu2; Fang, Chengnan3; Wang, Yang2,4; Sun, Mingju2; Wang, Changsong6,7; Wang, Jiao4; Yin, Peiyuan3; Hu, Chunxiu3 |
| 刊名 | CLINICAL CANCER RESEARCH
 |
| 出版日期 | 2018-01-15 |
| 卷号 | 24期号:2页码:474-485 |
| ISSN号 | 1078-0432 |
| DOI | 10.1158/1078-0432.CCR-17-1707 |
| 文献子类 | Article |
| 英文摘要 | Purpose: Metabolic reprogramming is frequently identified in hepatocellular carcinoma (HCC), which is the most common type of liver malignancy. The reprogrammed cellular metabolisms promote tumor cell survival, proliferation, angiogenesis, and metastasis. However, the mechanisms of this process remain unclear in HCC. |
| WOS关键词 | CANCER-CELLS ; C-MYC ; SORAFENIB RESISTANCE ; GLUTAMINE-METABOLISM ; TUMOR-SUPPRESSOR ; INHIBITION ; PROLIDASE ; GROWTH ; PROTEIN ; LIVER |
| WOS研究方向 | Oncology |
| 语种 | 英语 |
| WOS记录号 | WOS:000422883900022 |
| 出版者 | AMER ASSOC CANCER RESEARCH |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/168548]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 通讯作者 | Xu, Guowang; Liu, Yang |
| 作者单位 | 1.NINDS, Surg Neurol Branch, NIH, Bldg 36,Rm 4D04, Bethesda, MD 20892 USA 2.Chinese Acad Sci, Dalian Inst Chem Phys, Dept Biotechnol, Sci Res Ctr Translat Med, Dalian, Peoples R China 3.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, 457 Zhongshan Rd, Dalian 116023, Peoples R China 4.Dalian Univ, Sch Life Sci, Dalian, Peoples R China 5.Univ Chinese Acad Sci, Dalian, Peoples R China 6.Harbin Med Univ, Affiliated Hosp 1, Dept Anesthesiol, Harbin, Heilongjiang, Peoples R China 7.Harbin Med Univ, Affiliated Hosp 3, Dept Crit Care Med, Harbin, Heilongjiang, Peoples R China 8.Univ Cincinnati, Dept Med, Div Pulm Crit Care & Sleep Med, Cincinnati, OH USA |
| 推荐引用方式 GB/T 7714 | Tang, Ling,Zeng, Jun,Geng, Pengyu,et al. Global Metabolic Profiling Identifies a Pivotal Role of Proline and Hydroxyproline Metabolism in Supporting Hypoxic Response in Hepatocellular Carcinoma[J]. CLINICAL CANCER RESEARCH,2018,24(2):474-485. |
| APA | Tang, Ling.,Zeng, Jun.,Geng, Pengyu.,Fang, Chengnan.,Wang, Yang.,...&Liu, Yang.(2018).Global Metabolic Profiling Identifies a Pivotal Role of Proline and Hydroxyproline Metabolism in Supporting Hypoxic Response in Hepatocellular Carcinoma.CLINICAL CANCER RESEARCH,24(2),474-485. |
| MLA | Tang, Ling,et al."Global Metabolic Profiling Identifies a Pivotal Role of Proline and Hydroxyproline Metabolism in Supporting Hypoxic Response in Hepatocellular Carcinoma".CLINICAL CANCER RESEARCH 24.2(2018):474-485. |
入库方式： OAI收割
来源：大连化学物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。