Chamaejasmine B Induces the Anergy of Vascular Endothelial Cells to VEGFA Pro-angiogenic Signal by Autophagic Regulation of VEGFR2 in Breast Cancer
文献类型：期刊论文
| 作者 | Li, Qi2; Kan, Xiaoxi2; Yin, Jie1,2; Sun, Lidong2; Wang, Yajie2; Li, Yujie2; Yang, Qing2; Xiao, Hongbin3; Chen, Ying2; Weng, Xiaogang2 |
| 刊名 | FRONTIERS IN PHARMACOLOGY
 |
| 出版日期 | 2018-01-22 |
| 卷号 | 8 |
| ISSN号 | 1663-9812 |
| 关键词 | Chamaejasmine b Anti-angiogenesis Chemotherapy Breast Cancer Autophagy Vegfr2 |
| DOI | 10.3389/fphar.2017.00963 |
| 文献子类 | Article |
| 英文摘要 | The neovascularization functions essentially for malignant upgrading and predicts poor prognosis in multiple cancers, which make it the highly effective strategy for clinical treatment. Unfortunately, the known anti-angiogenic therapies show low effectiveness against breast cancer. Recently, rebalancing the pro-angiogenic property in microenvironment shows great advantages and attracts increasing attention for breast cancer treatment. Herein, we for the first time reported that Chamaejasmine B (ICJ), extracted from Stellera chamaejasme L., possessed potent anti-angiogenic effect in breast cancer. By Transwell, tube formation and aortic-ring assays, ICJ efficiently suppressed the neovascularization potential in tumor-HUVEC co-culture model. In Matrigel plug assay, the efficacy of ICJ was further identified in vivo. Mechanistically, with little influence on HUVEC apoptosis, ICJ obviously induced autophagy as proved by the elevated LC3I/II ratio, dotted distribution of LC3 and upregulated Beclin-1. Moreover, by associating with LC3 and in turn, inhibiting the level of VEGFR2, the anti-angiogenesis efficacy was closely dependent on the initiation of autophagy. Above results proved that, by attenuating the pro-angiogenic communication through VEGFR2, ICJ is a novel angiogenic inhibitor and will be a promising supplement for anti-angiogenic chemotherapy for breast cancer. |
| WOS关键词 | TUMOR ANGIOGENESIS ; METASTASIS ; THERAPY ; MECHANISMS ; INHIBITORS ; SUNITINIB ; COLONIZATION ; PERSPECTIVE ; CARCINOMA ; APOPTOSIS |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | FRONTIERS MEDIA SA |
| WOS记录号 | WOS:000422961500001 |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/168554]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 通讯作者 | Zhu, Xiaoxin |
| 作者单位 | 1.Capital Med Univ, Sch Tradit Chinese Med, Beijing, Peoples R China 2.China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing, Peoples R China 3.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Qi,Kan, Xiaoxi,Yin, Jie,et al. Chamaejasmine B Induces the Anergy of Vascular Endothelial Cells to VEGFA Pro-angiogenic Signal by Autophagic Regulation of VEGFR2 in Breast Cancer[J]. FRONTIERS IN PHARMACOLOGY,2018,8. |
| APA | Li, Qi.,Kan, Xiaoxi.,Yin, Jie.,Sun, Lidong.,Wang, Yajie.,...&Zhu, Xiaoxin.(2018).Chamaejasmine B Induces the Anergy of Vascular Endothelial Cells to VEGFA Pro-angiogenic Signal by Autophagic Regulation of VEGFR2 in Breast Cancer.FRONTIERS IN PHARMACOLOGY,8. |
| MLA | Li, Qi,et al."Chamaejasmine B Induces the Anergy of Vascular Endothelial Cells to VEGFA Pro-angiogenic Signal by Autophagic Regulation of VEGFR2 in Breast Cancer".FRONTIERS IN PHARMACOLOGY 8(2018). |
入库方式： OAI收割
来源：大连化学物理研究所
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