Identification of SPOP related metabolic pathways in prostate cancer
文献类型：期刊论文
| 作者 | Yan, Min1,2,3; Qi, Huan1; Li, Jia2,3; Ye, Guozhu2,3; Shao, Yaping2,3; Li, Tongming1; Liu, Jing1; Piao, Hai-Long1,3; Xu, Guowang2,3 |
| 刊名 | ONCOTARGET
 |
| 出版日期 | 2017-11-28 |
| 卷号 | 8期号:61页码:103032-103046 |
| 关键词 | Spop Metabolism |
| ISSN号 | 1949-2553 |
| DOI | 10.18632/oncotarget.21460 |
| 文献子类 | Article |
| 英文摘要 | Speckle-type POZ protein (SPOP), as a cullin-based E3 ubiquitin ligase, has been identified as one of the most frequently mutated genes in prostate cancer (PCa). However, whether SPOP mutations contribute to metabolic reprogramming in PCa remains unknown. Here, integrated studies of transcriptomics and metabolomics as well as lipidomics were performed in matched PCa tumor (PCT) and adjacent non-tumor (ANT) tissues, followed by correlation analysis of SPOP mutations with altered metabolic pathways in SPOP-mutated PCa patients. Interestingly, transcriptomics profiling showed that all SPOP mutations (with 16.7% frequency, 11/66) occurred at the conserved residues in the substrate binding domain of meprin and TRAF homology (MATH). The results of integrated analysis indicated that three metabolic pathways, including tricarboxylic acid (TCA) cycle, fatty acid metabolism and glycerophospholipid metabolism, exhibited obvious upregulation in SPOP-mutated PCT tissues. Furthermore, both correlation analyses based on integrated data and cBioportal revealed that FH, ELOVL2 and ACADL genes might be involved in SPOP-mutation-related upregulation of these metabolic pathways. Taken together, our study provided new insights in understanding the relationship between metabolic pathways and SPOP mutations in PCa. |
| WOS关键词 | ANDROGEN RECEPTOR ; POTENTIAL BIOMARKER ; TCA CYCLE ; RNA-SEQ ; PROGRESSION ; TRANSCRIPTOMICS ; DEGRADATION ; INTEGRATION ; MUTATIONS ; UBIQUITINATION |
| WOS研究方向 | Oncology ; Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000419562500025 |
| 出版者 | IMPACT JOURNALS LLC |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/168654]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 通讯作者 | Piao, Hai-Long; Xu, Guowang |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Sci Res Ctr Translat Med, Dalian 116023, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yan, Min,Qi, Huan,Li, Jia,et al. Identification of SPOP related metabolic pathways in prostate cancer[J]. ONCOTARGET,2017,8(61):103032-103046. |
| APA | Yan, Min.,Qi, Huan.,Li, Jia.,Ye, Guozhu.,Shao, Yaping.,...&Xu, Guowang.(2017).Identification of SPOP related metabolic pathways in prostate cancer.ONCOTARGET,8(61),103032-103046. |
| MLA | Yan, Min,et al."Identification of SPOP related metabolic pathways in prostate cancer".ONCOTARGET 8.61(2017):103032-103046. |
入库方式： OAI收割
来源：大连化学物理研究所
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