Nogo-B receptor promotes epithelial-mesenchymal transition in non-small cell lung cancer cells through the Ras/ERK/Snaill pathway
文献类型：期刊论文
| 作者 | Wu, Donghua1; Zhao, Baofeng2; Qi, Xiaoyu3,4,5; Peng, Fang1; Fu, Hailu1; Chi, Xinming1; Miao, Qing Robert3,4,5; Shao, Shujuan1 |
| 刊名 | CANCER LETTERS
 |
| 出版日期 | 2018-04-01 |
| 卷号 | 418页码:135-146 |
| 关键词 | Nogo-b Receptor Non-small Cell Lung Cancer Epithelial-mesenchymal Transition Metastasis Snail1 |
| ISSN号 | 0304-3835 |
| DOI | 10.1016/j.canlet.2018.01.030 |
| 文献子类 | Article |
| 英文摘要 | Nogo-B receptor (NgBR) is a specific receptor of Nogo-B that regulates vascular remodeling and angio-genesis. Previously, we found that NgBR promotes the membrane translocation and activation of Ras in breast cancer cells and enhances the chemoresistance of hepatocellular carcinoma cells to 5-fluorouracil. However, the role of NgBR in lung cancer has not yet been elucidated. In the present study, we found that NgBR knockdown inhibited epithelial-mesenchymal transition (EMT) in non-small cell lung cancer (NSCLC) cells in vitro and metastasis of NSCLC cells in vivo. In contrast, NgBR overexpression promoted EMT in and lung metastasis of NSCLC cells. At the molecular level, NgBR modulated the expression of EMT-related proteins and enhanced the protein expression of Snail1, a crucial transcription factor that represses epithelial cell protein marker E-cadherin. Moreover, we found that NgBR overexpression promoted the membrane localization of Ras and activation of downstream MEK/ERK signaling pathway and that NgBR knockdown by using a specific shRNA inversely affected the expression of EMT-related proteins in NSCLC cells. Thus, our results provide novel insights on the regulatory role of NgBR in the metastasis of NSCLC that should be investigated further for developing a therapeutic strategy for treating patients with NSCLC. (C) 2018 Elsevier B.V. All rights reserved. |
| WOS关键词 | TUMOR-CELLS ; RAS ; SNAIL ; TRANSCRIPTION ; STATISTICS ; ACTIVATION ; EXPRESSION ; CARCINOMA ; MORPHOGENESIS ; METASTASIS |
| WOS研究方向 | Oncology |
| 语种 | 英语 |
| WOS记录号 | WOS:000426139800014 |
| 出版者 | ELSEVIER IRELAND LTD |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/168738]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 通讯作者 | Miao, Qing Robert; Shao, Shujuan |
| 作者单位 | 1.Dalian Med Univ, Key Lab Prote, Dalian 116044, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China 3.Med Coll Wisconsin, Dept Surg, Childrens Res Inst, Div Pediat Surg, 8700 W Wisconsin Ave, Milwaukee, WI 53226 USA 4.Med Coll Wisconsin, Dept Pathol, Childrens Res Inst, Div Pediat Pathol, Milwaukee, WI 53226 USA 5.Med Coll Wisconsin, Dept Pharmacol & Toxicol, Milwaukee, WI 53226 USA |
| 推荐引用方式 GB/T 7714 | Wu, Donghua,Zhao, Baofeng,Qi, Xiaoyu,et al. Nogo-B receptor promotes epithelial-mesenchymal transition in non-small cell lung cancer cells through the Ras/ERK/Snaill pathway[J]. CANCER LETTERS,2018,418:135-146. |
| APA | Wu, Donghua.,Zhao, Baofeng.,Qi, Xiaoyu.,Peng, Fang.,Fu, Hailu.,...&Shao, Shujuan.(2018).Nogo-B receptor promotes epithelial-mesenchymal transition in non-small cell lung cancer cells through the Ras/ERK/Snaill pathway.CANCER LETTERS,418,135-146. |
| MLA | Wu, Donghua,et al."Nogo-B receptor promotes epithelial-mesenchymal transition in non-small cell lung cancer cells through the Ras/ERK/Snaill pathway".CANCER LETTERS 418(2018):135-146. |
入库方式： OAI收割
来源：大连化学物理研究所
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