Antrodia cinnamomea Oligosaccharides Suppress Lipopolysaccharide-Induced Inflammation through Promoting O-GlcNAcylation and Repressing p38/Akt Phosphorylation
文献类型：期刊论文
| 作者 | Zheng, Junping1,2,3,4; Jiao, Siming3,4; Li, Qiongyu3,4; Jia, Peiyuan3,4; Yin, Heng1; Zhao, Xiaoming1; Du, Yuguang3,4; Liu, Hongtao3,4,5 |
| 刊名 | MOLECULES
 |
| 出版日期 | 2018 |
| 卷号 | 23期号:1 |
| 关键词 | Antrodia Cinnamomea Akt Inflammation O-glcnacylation Oligosaccharides |
| ISSN号 | 1420-3049 |
| DOI | 10.3390/molecules23010051 |
| 文献子类 | Article |
| 英文摘要 | Antrodia cinnamomea (AC), an edible fungus growing in Taiwan, has various health benefits. This study was designed to examine the potential inhibitory effects of AC oligosaccharides on lipopolysaccharide (LPS)-induced inflammatory responses in vitro and in vivo. By trifluoroacetic acid degradation, two oligosaccharide products were prepared from AC polysaccharides at 90 degrees C (ACHO) or 25 degrees C (ACCO), which showed different oligosaccharide identities. Compared to ACCO, ACHO displayed better inhibitory effects on LPS-induced mRNA expression of pro-inflammatory cytokines including IL-6, IL-8, IL-1, TNF- and MCP-1 in macrophage cells. Further, ACHO significantly suppressed the inflammation in lung tissues of LPS-injected C57BL/6 mice. The potential anti-inflammatory molecular mechanism may be associated with the promotion of protein O-GlcNAcylation, which further skewed toward the marked suppression of p38 and Akt phosphorylation. Our results suggest that the suppressive effect of AC oligosaccharides on inflammation may be an effective approach for the prevention of inflammation-related diseases. |
| WOS关键词 | BETA-N-ACETYLGLUCOSAMINE ; LPS-INDUCED INFLAMMATION ; KAPPA-B ; CAMPHORATA MYCELIA ; MEDICINAL MUSHROOM ; POLYSACCHARIDES ; GLCNAC ; CELLS ; MODULATION ; ACTIVATION |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000425082500048 |
| 出版者 | MDPI AG |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/168760]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 通讯作者 | Du, Yuguang; Liu, Hongtao |
| 作者单位 | 1.Chinese Acad Sci, Liaoning Prov Key Lab Carbohydrates, Dalian Inst Chem Phys, Dalian 116023, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, State Key Lab Biochem Engn, PLA, Inst Proc Engn, Beijing 100190, Peoples R China 4.Chinese Acad Sci, Key Lab Biopharmaceut Prod & Formulat Engn, PLA, Inst Proc Engn, Beijing 100190, Peoples R China 5.Zhengzhou Inst Emerging Ind Technol, Zhengzhou 450000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zheng, Junping,Jiao, Siming,Li, Qiongyu,et al. Antrodia cinnamomea Oligosaccharides Suppress Lipopolysaccharide-Induced Inflammation through Promoting O-GlcNAcylation and Repressing p38/Akt Phosphorylation[J]. MOLECULES,2018,23(1). |
| APA | Zheng, Junping.,Jiao, Siming.,Li, Qiongyu.,Jia, Peiyuan.,Yin, Heng.,...&Liu, Hongtao.(2018).Antrodia cinnamomea Oligosaccharides Suppress Lipopolysaccharide-Induced Inflammation through Promoting O-GlcNAcylation and Repressing p38/Akt Phosphorylation.MOLECULES,23(1). |
| MLA | Zheng, Junping,et al."Antrodia cinnamomea Oligosaccharides Suppress Lipopolysaccharide-Induced Inflammation through Promoting O-GlcNAcylation and Repressing p38/Akt Phosphorylation".MOLECULES 23.1(2018). |
入库方式： OAI收割
来源：大连化学物理研究所
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