Short-chain chlorinated paraffins (SCCPs) induced thyroid disruption by enhancement of hepatic thyroid hormone influx and degradation in male Sprague Dawley rats
文献类型：期刊论文
| 作者 | Gong, Yufeng2; Zhang, Haijun2; Geng, Ningbo2; Xing, Liguo3; Fan, Jingfeng1; Luo, Yun2,4; Song, Xiaoyao2; Ren, Xiaoqian2,4; Wang, Feidi2,4; Chen, Jiping2 |
| 刊名 | SCIENCE OF THE TOTAL ENVIRONMENT
 |
| 出版日期 | 2018-06-01 |
| 卷号 | 625页码:657-666 |
| ISSN号 | 0048-9697 |
| 关键词 | Short-chain Chlorinated Paraffins Thyroid Disruption Hepatic Metabolism Thyroid Hormone Constitutive Androstane Receptor |
| DOI | 10.1016/j.scitotenv.2017.12.251 |
| 文献子类 | Article |
| 英文摘要 | Short-chain chlorinated paraffins (SCCPs) are known to disturb thyroid hormone (TH) homeostasis in rodents. However, the mechanism remains to be fully characterized. In this study, male Sprague Dawley rats received SCCPs (0, 1, 10, or 100 mg/kg/day) via gavage once a day for consecutive 28 days. Plasma and hepatic TH concentrations, thyrocyte structure, as well as thyroid and hepatic mRNA and protein levels of genes associated with TH homeostasis were examined. Moreover, we performed molecular docking to predict interactions between constitutive androstane receptor (CAR), a key regulator in xenobiotic-induced TH metabolism, with different SCCP molecules. Exposure to SCCPs significantly decreased the circulating free thyroxine (T-4) and triiodothyronine (T-3) levels, but increased thyroid-stimulating hormone (TSH) levels by a feedback mechanism. Decreased hepatic T-4 and increased hepatic T-3 levels were also seen after 100 mg/kg/day SCCPs exposure. SCCPs didn't show any significant effects on the expression of thyroid TH synthesis genes or thyrocyte structure. However, stimulation effects were observed for mRNA and protein levels of hepatic uridine diphosphoglucuronosyl transferase (UGT) 1A1 and organic anion transporter 2, suggesting an accelerated TH metabolism in rat liver. The increased cytochrome P450 2B1 but not 1A1 mRNA and protein levels indicated that the CAR signaling was activated by SCCPs exposure. According to docking analysis, SCCPs form hydrophobic interactions with CAR and the binding affinity shows dependency on chlorine content. Overall, our data showed that CAR implicated enhancement of hepatic TH influx and degradation could be the main cause for SCCPs induced TH deficiency in male rats. (C) 2017 Elsevier B.V. All rights reserved. |
| WOS关键词 | ARYL-HYDROCARBON RECEPTOR ; POLYBROMINATED DIPHENYL ETHERS ; HUMAN EXPOSURE ; POLYCHLORINATED-BIPHENYLS ; ENVIRONMENTAL CHEMICALS ; LACTATIONAL EXPOSURE ; IN-VIVO ; CHINA ; CAR ; METABOLISM |
| WOS研究方向 | Environmental Sciences & Ecology |
| 语种 | 英语 |
| 出版者 | ELSEVIER SCIENCE BV |
| WOS记录号 | WOS:000426356600067 |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/168812]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 通讯作者 | Chen, Jiping |
| 作者单位 | 1.Natl Marine Environm Monitoring Ctr, Dalian 116023, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China 3.Shenyang Res Inst Chem Ind Ltd, Safety Evaluat Ctr, Shenyang 110021, Liaoning, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gong, Yufeng,Zhang, Haijun,Geng, Ningbo,et al. Short-chain chlorinated paraffins (SCCPs) induced thyroid disruption by enhancement of hepatic thyroid hormone influx and degradation in male Sprague Dawley rats[J]. SCIENCE OF THE TOTAL ENVIRONMENT,2018,625:657-666. |
| APA | Gong, Yufeng.,Zhang, Haijun.,Geng, Ningbo.,Xing, Liguo.,Fan, Jingfeng.,...&Chen, Jiping.(2018).Short-chain chlorinated paraffins (SCCPs) induced thyroid disruption by enhancement of hepatic thyroid hormone influx and degradation in male Sprague Dawley rats.SCIENCE OF THE TOTAL ENVIRONMENT,625,657-666. |
| MLA | Gong, Yufeng,et al."Short-chain chlorinated paraffins (SCCPs) induced thyroid disruption by enhancement of hepatic thyroid hormone influx and degradation in male Sprague Dawley rats".SCIENCE OF THE TOTAL ENVIRONMENT 625(2018):657-666. |
入库方式： OAI收割
来源：大连化学物理研究所
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