Chitin Oligosaccharide Modulates Gut Microbiota and Attenuates High-Fat-Diet-Induced Metabolic Syndrome in Mice
文献类型：期刊论文
| 作者 | Zheng, Junping1,2,3,4; Cheng, Gong1,4; Li, Qiongyu1,4; Jiao, Siming1,4; Feng, Cui1,4; Zhao, Xiaoming2; Yin, Heng2; Du, Yuguang1,4; Liu, Hongtao1,4,5 |
| 刊名 | MARINE DRUGS
 |
| 出版日期 | 2018-02-01 |
| 卷号 | 16期号:2 |
| 关键词 | Chitin Oligosaccharide Gut Microbiota High-fat Diet Insulin Resistance Metabolic Syndrome |
| ISSN号 | 1660-3397 |
| DOI | 10.3390/md16020066 |
| 文献子类 | Article |
| 英文摘要 | Gut microbiota has been proved to be an indispensable link between nutrient excess and metabolic syndrome, and chitin oligosaccharide (NACOS) has displayed therapeutic effects on multiple diseases such as cancer and gastritis. In this study, we aim to confirm whether NACOS can ameliorate high-fat diet (HFD)-induced metabolic syndrome by rebuilding the structure of the gut microbiota community. Male C57BL/6J mice fed with HFD were treated with NACOS (1 mg/mL) in drinking water for five months. The results indicate that NACOS improved glucose metabolic disorder in HFD-fed mice and suppressed mRNA expression of the protein regulators related to lipogenesis, gluconeogenesis, adipocyte differentiation, and inflammation in adipose tissues. Additionally, NACOS inhibited the destruction of the gut barrier in HFD-treated mice. Furthermore, 16S ribosome RNA sequencing of fecal samples demonstrates that NACOS promoted the growth of beneficial intestinal bacteria remarkably and decreased the abundance of inflammogenic taxa. In summary, NACOS partly rebuilt the microbial community and improved the metabolic syndrome of HFD-fed mice. These data confirm the preventive effects of NACOS on nutrient excess-related metabolic diseases. |
| WOS关键词 | PANCREATIC-ISLET CELLS ; CHITOSAN OLIGOSACCHARIDE ; FECAL MICROBIOTA ; OBESE MICE ; DIABETES-MELLITUS ; RATS ; GLUCOSE ; SUPPLEMENTATION ; INFLAMMATION ; MODEL |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000427528800028 |
| 出版者 | MDPI |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/168876]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 通讯作者 | Du, Yuguang; Liu, Hongtao |
| 作者单位 | 1.Chinese Acad Sci, Inst Proc Engn, PLA, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Liaoning Prov Key Lab Carbohydrates, Dalian 116023, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Inst Proc Engn, PLA, Key Lab Biopharmaceut Prod & Formulat Engn, Beijing 100190, Peoples R China 5.Zhengzhou Inst Emerging Ind Technol, Zhengzhou 450000, Henan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zheng, Junping,Cheng, Gong,Li, Qiongyu,et al. Chitin Oligosaccharide Modulates Gut Microbiota and Attenuates High-Fat-Diet-Induced Metabolic Syndrome in Mice[J]. MARINE DRUGS,2018,16(2). |
| APA | Zheng, Junping.,Cheng, Gong.,Li, Qiongyu.,Jiao, Siming.,Feng, Cui.,...&Liu, Hongtao.(2018).Chitin Oligosaccharide Modulates Gut Microbiota and Attenuates High-Fat-Diet-Induced Metabolic Syndrome in Mice.MARINE DRUGS,16(2). |
| MLA | Zheng, Junping,et al."Chitin Oligosaccharide Modulates Gut Microbiota and Attenuates High-Fat-Diet-Induced Metabolic Syndrome in Mice".MARINE DRUGS 16.2(2018). |
入库方式： OAI收割
来源：大连化学物理研究所
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