Fast preparation of hybrid monolithic columns via photo-initiated thiol-yne polymerization for capillary liquid chromatography
文献类型：期刊论文
| 作者 | Ma, Shujuan2,3; Zhang, Haiyang2,3; Li, Ya2,3; Li, Yanan1,3; Zhang, Na1,3; Ou, Junjie3; Ye, Mingliang3; Wei, Yinmao2 |
| 刊名 | JOURNAL OF CHROMATOGRAPHY A
 |
| 出版日期 | 2018-02-23 |
| 卷号 | 1538页码:8-16 |
| 关键词 | Hybrid Monoliths Thiol-yne Click Reaction Photo-initiated Polymerization Capillary Liquid Chromatography 1 1 3-diethynyltetramethyl-disiloxane 6-hexanedithiol |
| ISSN号 | 0021-9673 |
| DOI | 10.1016/j.chroma.2018.01.028 |
| 文献子类 | Article |
| 英文摘要 | Although several approaches have been developed to fabricate hybrid monoliths, it would still take a few hours to finish the formation of monoliths. Herein, photo-initiated thiol-yne polymerization was first adopted to in situ fabricate hybrid monoliths within the confines of UV-transparent fused-silica capillary. A silicon-containing diyne (1,3-diethynyltetramethyl-disiloxane, DYDS) was copolymerized with three multithiols, 1,6-hexanedithiol, trimethylolpropane tris(3-mercaptopropionate) and pentaerythriol tetrakis(3-mercaptopropionate), by using a binary porogenic system of diethylene glycol diethyl ether (DEGDE)/poly(ethylene glycol) (PEG200) within 10 min. Several characterizations of three hybrid monoliths (assigned as I, II and III, respectively) were performed. The results showed that these hybrid monoliths possessed bicontinuous porous structure, which was remarkably different from that via typical free-radical polymerization. The highest column efficiency of 76,000 plates per meter for butylbenzene was obtained on the column I in reversed-phase liquid chromatography (RPLC). It was observed that the efficiencies for strong-retained butylbenzene were almost close to those of weak-retained benzene, indicating a retention-independent efficient performance of small molecules on hybrid column I. The surface area of this hybrid monolith was very small in the dry state (less than 10.0 m(2)/g), and the chromatographic behavior of hybrid monolithic columns would be possibly explained by radical-mediated step-growth process of thiol-yne polymerization. Finally, the column I was applied for separation of BSA tryptic digest by cLC-MS/MS, indicating satisfactory separation ability for complicated samples. (C) 2018 Elsevier B.V. All rights reserved. |
| WOS关键词 | ENE CLICK CHEMISTRY ; SMALL MOLECULES ; ACRYLATE POLYMERIZATION ; FACILE PREPARATION ; PERFORMANCE ; SEPARATION ; EFFICIENCY |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000426230700002 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/168886]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 通讯作者 | Wei, Yinmao |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Northwest Univ, Minist Educ, Coll Chem & Mat Sci, Key Lab Synth & Nat Funct Mol Chem, Xian 710069, Shaanxi, Peoples R China 3.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ma, Shujuan,Zhang, Haiyang,Li, Ya,et al. Fast preparation of hybrid monolithic columns via photo-initiated thiol-yne polymerization for capillary liquid chromatography[J]. JOURNAL OF CHROMATOGRAPHY A,2018,1538:8-16. |
| APA | Ma, Shujuan.,Zhang, Haiyang.,Li, Ya.,Li, Yanan.,Zhang, Na.,...&Wei, Yinmao.(2018).Fast preparation of hybrid monolithic columns via photo-initiated thiol-yne polymerization for capillary liquid chromatography.JOURNAL OF CHROMATOGRAPHY A,1538,8-16. |
| MLA | Ma, Shujuan,et al."Fast preparation of hybrid monolithic columns via photo-initiated thiol-yne polymerization for capillary liquid chromatography".JOURNAL OF CHROMATOGRAPHY A 1538(2018):8-16. |
入库方式： OAI收割
来源：大连化学物理研究所
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