Iridium-catalyzed Asymmetric Hydrogenation of Polycyclic Pyrrolo/Indolo[1,2-a]quinoxalines and Phenanthridines
文献类型：期刊论文
| 作者 | Shen, Hong-Qiang1; Hu, Shu-Bo1,2; Zhai, Xiao-Yong1; Zhou, Yong-Gui1 |
| 刊名 | ADVANCED SYNTHESIS & CATALYSIS
 |
| 出版日期 | 2018-04-03 |
| 卷号 | 360期号:7页码:1334-1339 |
| ISSN号 | 1615-4150 |
| 关键词 | Iridium Asymmetric Hydrogenation Polycyclic Heteroaromatics Dehydrogenative Rearomatization |
| DOI | 10.1002/adsc.201701450 |
| 文献子类 | Article |
| 英文摘要 | Owing to the dehydrogenative rearomatization of hydrogenation product and poisoning effect of nitrogen atom, asymmetric hydrogenation of polycyclic nitrogen-containing heteroaromatics is still a great challenge. Herein, through insitu protection of hydrogenation products with acetic anhydride to inhibit rearomatization and poisoning effect, a novel iridium-catalyzed enantioselective hydrogenation of polycyclic nitrogen-containing heteroaromatics - pyrrolo/indolo[1,2-a]quinoxalines and phenanthridines - has been successfully developed, providing a facile access to chiral dihydropyrrolo/indolo[1,2-a]quinoxalines and dihydrophenanthridines with up to 98% ee. The strategy features broad substrate scope, easy operation and potential medicinal application. |
| WOS关键词 | IN-SITU REGENERATION ; ENANTIOSELECTIVE HYDROGENATION ; HETEROAROMATIC-COMPOUNDS ; BRONSTED ACID ; 2,9-SUBSTITUTED 1,10-PHENANTHROLINES ; RECEPTOR ANTAGONISTS ; NAD(P)H MODELS ; DERIVATIVES ; REDUCTION ; IMINES |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| WOS记录号 | WOS:000429346800003 |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/168990]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 通讯作者 | Zhou, Yong-Gui |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shen, Hong-Qiang,Hu, Shu-Bo,Zhai, Xiao-Yong,et al. Iridium-catalyzed Asymmetric Hydrogenation of Polycyclic Pyrrolo/Indolo[1,2-a]quinoxalines and Phenanthridines[J]. ADVANCED SYNTHESIS & CATALYSIS,2018,360(7):1334-1339. |
| APA | Shen, Hong-Qiang,Hu, Shu-Bo,Zhai, Xiao-Yong,&Zhou, Yong-Gui.(2018).Iridium-catalyzed Asymmetric Hydrogenation of Polycyclic Pyrrolo/Indolo[1,2-a]quinoxalines and Phenanthridines.ADVANCED SYNTHESIS & CATALYSIS,360(7),1334-1339. |
| MLA | Shen, Hong-Qiang,et al."Iridium-catalyzed Asymmetric Hydrogenation of Polycyclic Pyrrolo/Indolo[1,2-a]quinoxalines and Phenanthridines".ADVANCED SYNTHESIS & CATALYSIS 360.7(2018):1334-1339. |
入库方式： OAI收割
来源：大连化学物理研究所
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