Stress Impacts the Regulation Neuropeptides in the Rat Hippocampus and Prefrontal Cortex
文献类型：期刊论文
| 作者 | Lozano-Montes, Laura1; Papilloud, Aurelie2; Zhao, Nan3; Ye, Xueting3; Zhang, Xiaozhe3; Sandi, Carmen2; Rainer, Gregor1; Li, Wenxue1 |
| 刊名 | PROTEOMICS
 |
| 出版日期 | 2018-04-01 |
| 卷号 | 18期号:7 |
| ISSN号 | 1615-9853 |
| 关键词 | Adulthood Stress Anxiety Depression Differential Analysis Hippocampus Neuropeptides Peripuberty Stress Prefrontal Cortex |
| DOI | 10.1002/pmic.201700408 |
| 文献子类 | Article |
| 英文摘要 | Adverse life experiences increase the lifetime risk to several stress-related psychopathologies, such as anxiety or depressive-like symptoms following stress in adulthood. However, the neurochemical modulations triggered by stress have not been fully characterized. Neuropeptides play an important role as signaling molecules that contribute to physiological regulation and have been linked to neurological and psychiatric diseases. However, little is known about the influence of stress on neuropeptide regulation in the brain. Here, we have performed an exploratory study of how neuropeptide expression at adulthood is modulated by experiencing a period of multiple stressful experiences. We have targeted hippocampus and prefrontal cortex (PFC) brain areas, which have previously been shown to be modulated by stressors, employing a targeted liquid chromatography-mass spectrometry (LC-MS) based approach that permits broad peptide coverage with high sensitivity. We found that in the hippocampus, Met-enkephalin, Met-enkephalin-Arg-Phe, and Met-enkephalin-Arg-Gly-Leu were upregulated, while Leu-enkephalin and Little SAAS were downregulated after stress. In the PFC area, Met-enkephalin-Arg-Phe, Met-enkephalin-Arg-Gly-Leu, peptide PHI-27, somatostatin-28 (AA1-12), and Little SAAS were all downregulated. This systematic evaluation of neuropeptide alterations in the hippocampus and PFC suggests that stressors impact neuropeptides and that neuropeptide regulation is brain-area specific. These findings suggest several potential peptide candidates, which warrant further investigations in terms of correlation with depression-associated behaviors. |
| WOS关键词 | VASOACTIVE INTESTINAL POLYPEPTIDE ; MAJOR DEPRESSIVE DISORDER ; EARLY-LIFE STRESS ; RESTRAINT STRESS ; INCREASED AGGRESSION ; PERIPUBERTY STRESS ; SOCIAL DEFICITS ; ANXIETY ; CHOLECYSTOKININ ; BRAIN |
| WOS研究方向 | Biochemistry & Molecular Biology |
| 语种 | 英语 |
| 出版者 | WILEY |
| WOS记录号 | WOS:000428733300006 |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/169092]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 通讯作者 | Zhang, Xiaozhe |
| 作者单位 | 1.Univ Fribourg, Dept Med, Fribourg, Switzerland 2.Ecole Polytech Fed Lausanne, Sch Life Sci, Brain Mind Inst, Lab Behav Genet, Lausanne, Switzerland 3.Chinese Acad Sci, Dalian Inst Chem Phys, Div Biol Technol, Dalian, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lozano-Montes, Laura,Papilloud, Aurelie,Zhao, Nan,et al. Stress Impacts the Regulation Neuropeptides in the Rat Hippocampus and Prefrontal Cortex[J]. PROTEOMICS,2018,18(7). |
| APA | Lozano-Montes, Laura.,Papilloud, Aurelie.,Zhao, Nan.,Ye, Xueting.,Zhang, Xiaozhe.,...&Li, Wenxue.(2018).Stress Impacts the Regulation Neuropeptides in the Rat Hippocampus and Prefrontal Cortex.PROTEOMICS,18(7). |
| MLA | Lozano-Montes, Laura,et al."Stress Impacts the Regulation Neuropeptides in the Rat Hippocampus and Prefrontal Cortex".PROTEOMICS 18.7(2018). |
入库方式： OAI收割
来源：大连化学物理研究所
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