Chitosan oligosaccharides improve the disturbance in glucose metabolism and reverse the dysbiosis of gut microbiota in diabetic mice
文献类型：期刊论文
| 作者 | Yin, Heng2; Liu, Hongtao1,4,5; Zheng, Junping1,2,3,4; Yuan, Xubing1,3,4; Cheng, Gong1,4; Jiao, Siming1,4; Feng, Cui1,4; Zhao, Xiaoming2; Du, Yuguang1,4 |
| 刊名 | CARBOHYDRATE POLYMERS
 |
| 出版日期 | 2018-06-15 |
| 卷号 | 190页码:77-86 |
| 关键词 | Chitosan Oligosaccharides Diabetes Gut Microbiota Intestinal Integrity Lipogenesis |
| ISSN号 | 0144-8617 |
| DOI | 10.1016/j.carbpol.2018.02.058 |
| 文献子类 | Article |
| 英文摘要 | The aim of this study is to investigate the effect of chitosan oligosaccharides (COS) on type 2 diabetes mellitus. Wild type C57BL/6J mice or diabetic db/db mice were treated with vehicle or COS for three months. COS treatment significantly decreased the blood glucose (P < 0.01) and reversed the insulin resistance (P < 0.05) in db/db mice, which was accompanied by suppressing the inflammation mediators (P < 0.05), down-regulating the lipogenesis (P < 0.01) and inhibiting the adipocyte differentiation (P < 0.05) in white adipose tissue. Additionally, COS treatment inhibited the reduction of occludin (P < 0.01) and relieved the gut dysbiosis in diabetic mice by promoting Akkermansia (P < 0.01) and suppressing Helicobacter (P < 0.05). Spearman's correlation analysis indicates that the COS-modulated bacteria are positively correlated with inflammation, hyperglycemia and dyslipidemia. The functional profiling based on the microbiota composition implicated that COS treatment may regulate the metabolic pathways of gut microbiota. In summary, COS treatment remarkably improved the glucose metabolism and reshaped the unbalanced gut microbiota of diabetic mice. Our study provided the evidence for application of COS to the treatment of diabetes mellitus. |
| WOS关键词 | INTESTINAL MICROBIOTA ; INSULIN-RESISTANCE ; BARRIER FUNCTION ; CHITOOLIGOSACCHARIDES ; OLIGOFRUCTOSE ; INDIVIDUALS ; ENDOTOXEMIA ; EXPRESSION ; OBESITY ; INULIN |
| WOS研究方向 | Chemistry ; Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000429425500009 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/169106]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 通讯作者 | Liu, Hongtao; Du, Yuguang |
| 作者单位 | 1.Chinese Acad Sci, PLA, Inst Proc Engn, Key Lab Biopharmaceut Prod & Formulat Engn, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Liaoning Prov Key Lab Carbohydrates, Dalian 116023, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Chinese Acad Sci, PLA, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 5.Zhengzhou Inst Emerging Ind Technol, Zhengzhou 450000, Henan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yin, Heng,Liu, Hongtao,Zheng, Junping,et al. Chitosan oligosaccharides improve the disturbance in glucose metabolism and reverse the dysbiosis of gut microbiota in diabetic mice[J]. CARBOHYDRATE POLYMERS,2018,190:77-86. |
| APA | Yin, Heng.,Liu, Hongtao.,Zheng, Junping.,Yuan, Xubing.,Cheng, Gong.,...&Du, Yuguang.(2018).Chitosan oligosaccharides improve the disturbance in glucose metabolism and reverse the dysbiosis of gut microbiota in diabetic mice.CARBOHYDRATE POLYMERS,190,77-86. |
| MLA | Yin, Heng,et al."Chitosan oligosaccharides improve the disturbance in glucose metabolism and reverse the dysbiosis of gut microbiota in diabetic mice".CARBOHYDRATE POLYMERS 190(2018):77-86. |
入库方式： OAI收割
来源：大连化学物理研究所
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