Analyses of gut microbiota and plasma bile acids enable stratification of patients for antidiabetic treatment
文献类型：期刊论文
| 作者 | Ren, Huahui4,5,7; Su, Qing9; Zhang, Hongmei9; Yang, Jialin10; Wang, Xiaoling11; Zhao, Xinjie11; Gu, Weiqiong3; Bi, Yufang3; Peng, Yongde12; Xu, Xiaoqiang2,4 |
| 刊名 | NATURE COMMUNICATIONS
 |
| 出版日期 | 2017-11-27 |
| 卷号 | 8 |
| ISSN号 | 2041-1723 |
| DOI | 10.1038/s41467-017-01682-2 |
| 文献子类 | Article |
| 英文摘要 | Antidiabetic medication may modulate the gut microbiota and thereby alter plasma and faecal bile acid (BA) composition, which may improve metabolic health. Here we show that treatment with Acarbose, but not Glipizide, increases the ratio between primary BAs and secondary BAs and plasma levels of unconjugated BAs in treatment-naive type 2 diabetes (T2D) patients, which may beneficially affect metabolism. Acarbose increases the relative abundances of Lactobacillus and Bifidobacterium in the gut microbiota and depletes Bacteroides, thereby changing the relative abundance of microbial genes involved in BA metabolism. Treatment outcomes of Acarbose are dependent on gut microbiota compositions prior to treatment. Compared to patients with a gut microbiota dominated by Prevotella, those with a high abundance of Bacteroides exhibit more changes in plasma BAs and greater improvement in metabolic parameters after Acarbose treatment. Our work highlights the potential for stratification of T2D patients based on their gut microbiota prior to treatment. |
| WOS关键词 | FARNESOID-X-RECEPTOR ; INSULIN-RESISTANCE ; BARIATRIC SURGERY ; RANDOMIZED-TRIAL ; SERUM METABOLOME ; METFORMIN ; GLUCOSE ; ENTEROTYPES ; METAGENOME ; ACARBOSE |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| 出版者 | NATURE PUBLISHING GROUP |
| WOS记录号 | WOS:000416293600001 |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/169258]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 通讯作者 | Kristiansen, Karsten; Ning, Guang; Wang, Weiqing |
| 作者单位 | 1.Natl Inst Nutr & Seafood Res NIFES, N-5817 Bergen, Norway 2.Univ Chinese Acad Sci, BGI Educ Ctr, Shenzhen 518083, Peoples R China 3.Shanghai Jiao Tong Univ, Shanghai Natl Res Ctr Endocrine & Metab Dis, Ruijin Hosp,State Key Lab Med Genom, Shanghai Inst Endocrine & Metab Dis,Sch Med, Shanghai 200025, Peoples R China 4.China Natl GeneBank Shenzhen, BGI Shenzhen, Shenzhen 518083, Peoples R China 5.BGI Shenzhen, Shenzhen Key Lab Human Commensal Microorganisms &, Shenzhen 518083, Peoples R China 6.Univ Copenhagen, Dept Biol, Lab Genom & Mol Biomed, DK-2100 Copenhagen, Denmark 7.BGI Shenzhen, Shenzhen Engn Lab Detect & Intervent Human Intest, Shenzhen 518083, Peoples R China 8.Shanghai Jiao Tong Univ, Med Sch, Renji Hosp, Shanghai 200127, Peoples R China 9.Shanghai Jiao Tong Univ, Med Sch, Xinhua Hosp, Shanghai 200092, Peoples R China 10.Fudan Univ, Med Sch, MinHang Cent Hosp, Shanghai 201100, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ren, Huahui,Su, Qing,Zhang, Hongmei,et al. Analyses of gut microbiota and plasma bile acids enable stratification of patients for antidiabetic treatment[J]. NATURE COMMUNICATIONS,2017,8. |
| APA | Ren, Huahui.,Su, Qing.,Zhang, Hongmei.,Yang, Jialin.,Wang, Xiaoling.,...&Ma, Jing.(2017).Analyses of gut microbiota and plasma bile acids enable stratification of patients for antidiabetic treatment.NATURE COMMUNICATIONS,8. |
| MLA | Ren, Huahui,et al."Analyses of gut microbiota and plasma bile acids enable stratification of patients for antidiabetic treatment".NATURE COMMUNICATIONS 8(2017). |
入库方式： OAI收割
来源：大连化学物理研究所
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