Metabolomics biomarker analysis of threatened abortion in polycystic ovary syndrome: a clinical discovery study
文献类型：期刊论文
| 作者 | Wang, Wei2; Zhao, Xinjie1,4; Feng, Xiaoling2; Chen, Lu2; Li, Na2; Zhao, Yan2; Han, Qimao3; Wang, Xiaolin1,4; Ma, Liping2 |
| 刊名 | RSC ADVANCES
 |
| 出版日期 | 2017 |
| 卷号 | 7期号:83页码:52923-52929 |
| ISSN号 | 2046-2069 |
| DOI | 10.1039/c6ra27357b |
| 文献子类 | Article |
| 英文摘要 | Metabolomics is the comprehensive assessment of endogenous metabolites of a biological system in a holistic context. Threatened abortion in polycystic ovary syndrome (PCOS) is a heterogeneous disorder with a miscarriage rate of up to 30-50% in women. However, metabolic changes regulated by threatened abortion in women with polycystic ovary syndrome are not clearly understood. Current pregnancy screening tools to identify women with PCOS that are at risk of threatened abortion lack both specificity and sensitivity. In this study, using an advanced metabolomics platform based on ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS), we found that pregnancy significantly altered the profile of metabolites in the plasma of women with PCOS. Mothers with PCOS and healthy controls could be clustered into two distinct groups based on multivariate statistical analysis. The current metabolomics approach based on UPLC-QTOF-MS indicated 7 ions (6 in the positive mode and 1 in the negative mode) as differentiating metabolites which, to some extent, contribute to the progress of threatened abortion. All these different metabolites led to abnormalities of the fatty acids, lipid metabolism and beta-oxidation of fatty acids in mothers with PCOS. This study was designed to explore the holistic metabolomic profile of threatened abortion as a result of PCOS. To our knowledge, this work is the first report using a metabolomic approach to propose metabolic changes in plasma in the threatened abortion of women with PCOS. Thus, our method is an efficient procedure for the pathogenesis of threatened abortion with mothers with PCOS. |
| WOS关键词 | CHROMATOGRAPHY-MASS SPECTROMETRY ; GESTATIONAL DIABETES-MELLITUS ; L-CARNITINE ; DIET ; METABOLISM ; PREDICTION ; PLASMA ; ROLES ; RISK ; LDL |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000415349700059 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/169274]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 通讯作者 | Zhao, Xinjie; Feng, Xiaoling |
| 作者单位 | 1.Chinese Acad Sci, Key Lab Separat Sci Analyt Chem, Dalian Inst Chem Phys, Dalian 116023, Peoples R China 2.Heilongjiang Univ Chinese Med, Dept Gynecol, Affiliated Hosp 1, Heping Rd 26, Harbin 150040, Heilongjiang, Peoples R China 3.Heilongjiang Univ Chinese Med, Dept Rheumatol, Affiliated Hosp 1, Heping Rd 26, Harbin 150040, Heilongjiang, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Wei,Zhao, Xinjie,Feng, Xiaoling,et al. Metabolomics biomarker analysis of threatened abortion in polycystic ovary syndrome: a clinical discovery study[J]. RSC ADVANCES,2017,7(83):52923-52929. |
| APA | Wang, Wei.,Zhao, Xinjie.,Feng, Xiaoling.,Chen, Lu.,Li, Na.,...&Ma, Liping.(2017).Metabolomics biomarker analysis of threatened abortion in polycystic ovary syndrome: a clinical discovery study.RSC ADVANCES,7(83),52923-52929. |
| MLA | Wang, Wei,et al."Metabolomics biomarker analysis of threatened abortion in polycystic ovary syndrome: a clinical discovery study".RSC ADVANCES 7.83(2017):52923-52929. |
入库方式： OAI收割
来源：大连化学物理研究所
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