A lysosomal probe for monitoring of pH in living cells and ovarian tumour
文献类型：期刊论文
| 作者 | Li, Bo1; Ge, Guang Bo2; Peng, Xiaojun1; Liu, Fengyu1; Sun, Shiguo3; Wen, Lanlan1; Yuan, Ye1; Zhang, Ran1 |
| 刊名 | DYES AND PIGMENTS
 |
| 出版日期 | 2017-04-01 |
| 卷号 | 139页码:318-325 |
| 关键词 | Monitoring Ph Lysosome Fluorescent Probe Cells Ovarian Tumour |
| ISSN号 | 0143-7208 |
| DOI | 10.1016/j.dyepig.2016.12.043 |
| 文献子类 | Article |
| 英文摘要 | Intracellular pH is important in regulating various cellular behaviour and pathological conditions. We synthesised a rhodamine-based lysosomal pH probe (hereafter referred to as RD) with a pKa of 4.10. The probe exhibited favourable "on-off' reversibility between pH 3.25 and 7.20 for at least five cycles. RD can be employed to distinguish cancer cells from normal cells on the basis of different fluorescence response. RD performed well in the detection of lysosomal pH induced by artesunate, chloroquine and dexamethasone in MCF-7 cells. The intense fluorescence of RD in ovarian tumour indicated the higher acidity in tumour tissues than that in normal tissues. Furthermore, RD worked well in the imaging of excised mouse stomach and living mice under acidic stimulation. These data demonstrate the applicability of RD in monitoring pH in complex biological systems.(C) 2016 Elsevier Ltd. All rights reserved. |
| WOS关键词 | RATIOMETRIC FLUORESCENT-PROBE ; IN-VIVO ; CANCER-CELLS ; INTRACELLULAR PH ; RHODAMINE-B ; MITOCHONDRIA ; SENSOR ; PROVIDES ; OXYGEN |
| WOS研究方向 | Chemistry ; Engineering ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000394063800037 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/169516]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 通讯作者 | Liu, Fengyu; Sun, Shiguo |
| 作者单位 | 1.Dalian Univ Technol, Sch Chem, State Key Lab Fine Chem, 2 Linggong Rd, Dalian 116023, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China 3.Shihezi Univ, Sch Pharm, Minist Educ, Key Lab Xinjiang Endem Phytomed Resources, Shihezi 832000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Bo,Ge, Guang Bo,Peng, Xiaojun,et al. A lysosomal probe for monitoring of pH in living cells and ovarian tumour[J]. DYES AND PIGMENTS,2017,139:318-325. |
| APA | Li, Bo.,Ge, Guang Bo.,Peng, Xiaojun.,Liu, Fengyu.,Sun, Shiguo.,...&Zhang, Ran.(2017).A lysosomal probe for monitoring of pH in living cells and ovarian tumour.DYES AND PIGMENTS,139,318-325. |
| MLA | Li, Bo,et al."A lysosomal probe for monitoring of pH in living cells and ovarian tumour".DYES AND PIGMENTS 139(2017):318-325. |
入库方式： OAI收割
来源：大连化学物理研究所
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