Expanding the product portfolio of fungal type I fatty acid synthases
文献类型：期刊论文
| 作者 | Nielsen, Jens1,3,4,7,8; Zhu, Zhiwei1,2,3; Zhou, Yongjin J.1,3; Krivoruchko, Anastasia1,3,4; Grininger, Martin5; Zhao, Zongbao K.2,6 |
| 刊名 | NATURE CHEMICAL BIOLOGY
 |
| 出版日期 | 2017-04-01 |
| 卷号 | 13期号:4页码:360-+ |
| ISSN号 | 1552-4450 |
| 文献子类 | Article |
| 英文摘要 | Fungal type I fatty acid synthases (FASs) are mega-enzymes with two separated, identical compartments, in which the acyl carrier protein (ACP) domains shuttle substrates to catalytically active sites embedded in the chamber wall. We devised synthetic FASs by integrating heterologous enzymes into the reaction chambers and demonstrated their capability to convert acyl-ACP or acyl-CoA from canonical fatty acid biosynthesis to short/ medium-chain fatty acids and methyl ketones. |
| WOS关键词 | SACCHAROMYCES-CEREVISIAE ; RHODOSPORIDIUM-TORULOIDES ; YEAST ; EXPRESSION ; GENES ; FAS |
| WOS研究方向 | Biochemistry & Molecular Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000397001800007 |
| 出版者 | NATURE PUBLISHING GROUP |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/169530]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 通讯作者 | Nielsen, Jens; Zhao, Zongbao K. |
| 作者单位 | 1.Chalmers, Dept Biol & Biol Engn, Gothenburg, Sweden 2.Chinese Acad Sci, Dalian Inst Chem Phys, Div Biotechnol, Dalian, Peoples R China 3.Chalmers, Novo Nordisk Fdn Ctr Biosustainabil, Gothenburg, Sweden 4.Chalmers, Biopetrolia AB, Syst & Synthet Biol, Gothenburg, Sweden 5.Goethe Univ Frankfurt, Inst Organ Chem & Chem Biol, Buchmann Inst Mol Life Sci, Cluster Excellence Macromol Complexes, Frankfurt, Germany 6.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian Natl Lab Clean Energy, Dalian, Peoples R China 7.Tech Univ Denmark, Novo Nordisk Fdn Ctr Biosustainabil, Horsholm, Denmark 8.Royal Inst Technol, Sci Life Lab, Stockholm, Sweden |
| 推荐引用方式 GB/T 7714 | Nielsen, Jens,Zhu, Zhiwei,Zhou, Yongjin J.,et al. Expanding the product portfolio of fungal type I fatty acid synthases[J]. NATURE CHEMICAL BIOLOGY,2017,13(4):360-+. |
| APA | Nielsen, Jens,Zhu, Zhiwei,Zhou, Yongjin J.,Krivoruchko, Anastasia,Grininger, Martin,&Zhao, Zongbao K..(2017).Expanding the product portfolio of fungal type I fatty acid synthases.NATURE CHEMICAL BIOLOGY,13(4),360-+. |
| MLA | Nielsen, Jens,et al."Expanding the product portfolio of fungal type I fatty acid synthases".NATURE CHEMICAL BIOLOGY 13.4(2017):360-+. |
入库方式： OAI收割
来源：大连化学物理研究所
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