中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
pH-dependent absorption spectra of rhodopsin mutant E113Q: On the role of counterions and protein

文献类型:期刊论文

作者Alsaedi, Ahmed2; Xie, Peng1; Zhou, Panwang1; Zhang, Yan1
刊名SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
出版日期2017-03-05
卷号174页码:25-31
关键词Spectra Tuning Qm/mm E113q Rhodopsin Hydrogen-bond Anion Biosensor
ISSN号1386-1425
DOI10.1016/j.saa.2016.11.015
文献子类Article
英文摘要The absorption spectra of bovine rhodopsin mutant E113Q in solutions were investigated at the molecular level by using a hybrid quantum mechanics/molecular mechanics (QM/MM) method. The calculations suggest the mechanism of the absorption variations of E113Q at different pH values. The results indicate that the polarizations of the counterions in the vicinity of Schiff base under protonation and unprotonation states of the mutant E113Q would be a crucial factor to change the energy gap of the retinal to tune the absorption spectra. Glu-181 residue, which is close to the chromophore, cannot serve as the counterion of the protonated Schiff base of E113Q in dark state. Moreover, the results of the absorption maximum in mutant E113Q with the various anions (Cl-, Br-, I- and NO3-) manifested that the mutant E113Q could have the potential for use as a template of anion biosensors at visible wavelength. (C) 2016 Elsevier B.V. All rights reserved.
WOS关键词COUPLED-RECEPTOR RHODOPSIN ; RETINAL CHROMOPHORE ; BOVINE RHODOPSIN ; VISUAL PIGMENTS ; ENERGY-STORAGE ; GLUTAMIC-ACID ; FORCE-FIELDS ; THEORY LEVEL ; SCHIFF-BASE ; STATE
WOS研究方向Spectroscopy
语种英语
WOS记录号WOS:000393628500004
出版者PERGAMON-ELSEVIER SCIENCE LTD
源URL[http://cas-ir.dicp.ac.cn/handle/321008/169644]  
专题大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者Zhang, Yan
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Mol React Dynam, Dalian 116023, Liaoning, Peoples R China
2.King Abdulaziz Univ, Nonlinear Anal & Appl Math NAAM Res Grp, Dept Math, Fac Sci, Jeddah 21589, Saudi Arabia
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Alsaedi, Ahmed,Xie, Peng,Zhou, Panwang,et al. pH-dependent absorption spectra of rhodopsin mutant E113Q: On the role of counterions and protein[J]. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,2017,174:25-31.
APA Alsaedi, Ahmed,Xie, Peng,Zhou, Panwang,&Zhang, Yan.(2017).pH-dependent absorption spectra of rhodopsin mutant E113Q: On the role of counterions and protein.SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,174,25-31.
MLA Alsaedi, Ahmed,et al."pH-dependent absorption spectra of rhodopsin mutant E113Q: On the role of counterions and protein".SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY 174(2017):25-31.

入库方式: OAI收割

来源:大连化学物理研究所

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