Synthesis of (+)-Lysergol and Its Analogues To Assess Serotonin Receptor Activity
文献类型：期刊论文
| 作者 | Yuan, Haosen1; Guo, Zhixian1; Luo, Tuoping1,2 |
| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2017-02-03 |
| 卷号 | 19期号:3页码:624-627 |
| ISSN号 | 1523-7060 |
| DOI | 10.1021/acs.orglett.6b03779 |
| 文献子类 | Article |
| 英文摘要 | An efficient synthesis of ergot alkaloid lysergol and its analogues is described, providing compounds for functional evaluation at the human.5-HT1A, 5-HT2A, 5-HT2B, or 5-HT2C receptors. Key features of the synthesis include the development of a tandem reaction to construet the multifunctionalized piperidine skeleton and use of a rhodium catalyzed [3 + 2] annulation in the late-stage indole formation. |
| WOS关键词 | RING-CLOSING METATHESIS ; (+/-)-LYSERGIC ACID ; ERGOT ALKALOIDS ; LYSERGIC-ACID ; ECONOMICAL SYNTHESIS ; 5-HT2A RECEPTORS ; 4-EXO-DIG ; ERGOLINES ; AGONISTS ; LIGANDS |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000393539900050 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/169654]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 通讯作者 | Luo, Tuoping |
| 作者单位 | 1.Peking Univ, Key Lab Bioorgan Chem & Mol Engn, Minist Educ, Beijing Natl Lab Mol Sci,Coll Chem & Mol Engn, Beijing 100871, Peoples R China 2.Peking Univ, Acad Adv Interdisciplinary Studies, Peking Tsinghua Ctr Life Sci, Beijing 100871, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yuan, Haosen,Guo, Zhixian,Luo, Tuoping. Synthesis of (+)-Lysergol and Its Analogues To Assess Serotonin Receptor Activity[J]. ORGANIC LETTERS,2017,19(3):624-627. |
| APA | Yuan, Haosen,Guo, Zhixian,&Luo, Tuoping.(2017).Synthesis of (+)-Lysergol and Its Analogues To Assess Serotonin Receptor Activity.ORGANIC LETTERS,19(3),624-627. |
| MLA | Yuan, Haosen,et al."Synthesis of (+)-Lysergol and Its Analogues To Assess Serotonin Receptor Activity".ORGANIC LETTERS 19.3(2017):624-627. |
入库方式： OAI收割
来源：大连化学物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。