Ion mobility spectrometry as a simple and rapid method to measure the plasma propofol concentrations for intravenous anaesthesia monitoring
文献类型：期刊论文
| 作者 | Gong, Yulei1; Li, Haiyang2; Wang, Xin2; Zhou, Qinghua2; Jiang, Dandan2; Li, Enyou1 |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2016-11-21 |
| 卷号 | 6 |
| ISSN号 | 2045-2322 |
| DOI | 10.1038/srep37525 |
| 文献子类 | Article |
| 英文摘要 | The plasma propofol concentration is important information for anaesthetists to monitor and adjust the anaesthesia depth for patients during a surgery operation. In this paper, a stand-alone ion mobility spectrometer (IMS) was constructed for the rapid measurement of the plasma propofol concentrations. Without any sample pre-treatment, the plasma samples were dropped on a piece of glass microfiber paper and then introduced into the IMS cell by the thermal desorption directly. Each individual measurement could be accomplished within 1 min. For the plasma propofol concentrations from 1 to 12 mu g mL(-1), the IMS response was linear with a correlation coefficient R-2 of 0.998, while the limit of detection was evaluated to be 0.1 mu g mL(-1). These measurement results did meet the clinical application requirements. Furthermore, other clinically-often-used drugs, including remifentanil, flurbiprofen and atracurium, were found no significant interference with the qualitative and quantitative analysis of the plasma propofol. The plasma propofol concentrations measured by IMS were correlated well with those measured by the high performance liquid chromatography (HPLC). The results confirmed an excellent agreement between these two methods. Finally, this method was applied to monitor the plasma propofol concentrations for a patient undergoing surgery, demonstrating its capability of anaesthesia monitoring in real clinical environments. |
| WOS关键词 | PERFORMANCE LIQUID-CHROMATOGRAPHY ; TANDEM MASS-SPECTROMETRY ; SOLID-PHASE EXTRACTION ; SENSITIVE DETECTION ; ONLINE MEASUREMENT ; WHOLE-BLOOD ; PHARMACOKINETICS ; REMIFENTANIL ; GLUCURONIDE ; EXPLOSIVES |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000388083100001 |
| 出版者 | NATURE PUBLISHING GROUP |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/169738]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 通讯作者 | Li, Haiyang |
| 作者单位 | 1.Harbin Med Univ, Affiliated Hosp 1, Dept Anesthesiol, Harbin 150001, Heilongjiang, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Liaoning, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gong, Yulei,Li, Haiyang,Wang, Xin,et al. Ion mobility spectrometry as a simple and rapid method to measure the plasma propofol concentrations for intravenous anaesthesia monitoring[J]. SCIENTIFIC REPORTS,2016,6. |
| APA | Gong, Yulei,Li, Haiyang,Wang, Xin,Zhou, Qinghua,Jiang, Dandan,&Li, Enyou.(2016).Ion mobility spectrometry as a simple and rapid method to measure the plasma propofol concentrations for intravenous anaesthesia monitoring.SCIENTIFIC REPORTS,6. |
| MLA | Gong, Yulei,et al."Ion mobility spectrometry as a simple and rapid method to measure the plasma propofol concentrations for intravenous anaesthesia monitoring".SCIENTIFIC REPORTS 6(2016). |
入库方式： OAI收割
来源：大连化学物理研究所
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