Differential Amino Acid, Carbohydrate and Lipid Metabolism Perpetuations Involved in a Subtype of Rheumatoid Arthritis with Chinese Medicine Cold Pattern
文献类型：期刊论文
| 作者 | Kong, Hongwei4; Guo, Hongtao2; Niu, Xuyan3; Gu, Yan4,5; Lu, Cheng1,3; Xiao, Cheng6,7; Yue, Kevin1; Zhang, Ge1; Pan, Xiaohua8; Jiang, Miao3 |
| 刊名 | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
 |
| 出版日期 | 2016-10-01 |
| 卷号 | 17期号:10 |
| 关键词 | Rheumatoid Arthritis Traditional Chinese Medicine Cold Pattern Heat Pattern Metabolic Pathways |
| ISSN号 | 1422-0067 |
| DOI | 10.3390/ijms17101757 |
| 文献子类 | Article |
| 英文摘要 | Pattern classification is a key approach in Traditional Chinese Medicine (TCM), and it is used to classify the patients for intervention selection accordingly. TCM cold and heat patterns, two main patterns of rheumatoid arthritis (RA) had been explored with systems biology approaches. Different regulations of apoptosis were found to be involved in cold and heat classification in our previous works. For this study, the metabolic profiling of plasma was explored in RA patients with typical TCM cold or heat patterns by integrating liquid chromatography/mass spectrometry (LC/MS) and gas chromatography/mass spectrometry (GC/MS) platforms in conjunction with the Ingenuity Pathway Analysis (IPA) software. Three main processes of metabolism, including amino acid, carbohydrate and lipid were focused on for function analysis. The results showed that 29 and 19 differential metabolites were found in cold and heat patterns respectively, compared with healthy controls. The perturbation of amino acid metabolism (increased essential amino acids), carbohydrate metabolism (galactose metabolism) and lipid metabolism, were found to be involved in both cold and heat pattern RA. In particular, more metabolic perturbations in protein and collagen breakdown, decreased glycolytic activity and aerobic oxidation, and increased energy utilization associated with RA cold pattern patients. These findings may be useful for obtaining a better understanding of RA pathogenesis and for achieving a better efficacy in RA clinical practice. |
| WOS关键词 | MASS-SPECTROMETRY ; SYSTEMS BIOLOGY ; CARDIOVASCULAR RISK ; BIOMARKERS ; PLASMA ; METABONOMICS ; DISCOVERY ; DISEASE ; PROTEOMICS ; GENES |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000387768300019 |
| 出版者 | MDPI AG |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/169754]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 通讯作者 | Xu, Guowang; Lu, Aiping |
| 作者单位 | 1.Hong Kong Baptist Univ, Inst Adv Translat Med Bone & Joint Dis, Sch Chinese Med, Kowloon Tong 00852, Hong Kong, Peoples R China 2.Henan Univ TCM, Affiliated Hosp 1, Dept Rheumatol, Zhengzhou 450000, Peoples R China 3.China Acad Chinese Med Sci, Inst Basic Res Clin Med, Beijing 100700, Peoples R China 4.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China 5.Shanxi Datong Univ, Sch Med, Datong 037009, Peoples R China 6.China Japan Friendship Hosp, Dept Sci Res Adm, Beijing 100029, Peoples R China 7.People Hosp Yichun City, Dept Rheumatol, Yichun 336000, Peoples R China 8.Jinan Univ, Inst Biomed Guangzhou, Jinan Univ & Hong Kong Baptist Univ Joint Lab Inn, Guangzhou 510632, Guangdong, Peoples R China 9.China Acad Chinese Med Sci, Inst Basic Theory TCM, Beijing 100700, Peoples R China 10.Shanghai Municipal Educ Commiss, E Inst Chinese Tradit Internal Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Kong, Hongwei,Guo, Hongtao,Niu, Xuyan,et al. Differential Amino Acid, Carbohydrate and Lipid Metabolism Perpetuations Involved in a Subtype of Rheumatoid Arthritis with Chinese Medicine Cold Pattern[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2016,17(10). |
| APA | Kong, Hongwei.,Guo, Hongtao.,Niu, Xuyan.,Gu, Yan.,Lu, Cheng.,...&Lu, Aiping.(2016).Differential Amino Acid, Carbohydrate and Lipid Metabolism Perpetuations Involved in a Subtype of Rheumatoid Arthritis with Chinese Medicine Cold Pattern.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,17(10). |
| MLA | Kong, Hongwei,et al."Differential Amino Acid, Carbohydrate and Lipid Metabolism Perpetuations Involved in a Subtype of Rheumatoid Arthritis with Chinese Medicine Cold Pattern".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 17.10(2016). |
入库方式： OAI收割
来源：大连化学物理研究所
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