Identification of Arginine and Its "Downstream" Molecules as Potential Markers of Breast Cancer
文献类型：期刊论文
| 作者 | Jing, Yu2; Hu, Lu2; Gao, Yu2; Cao, Yunfeng1,3; Zhang, Yinxu2; Xu, Minghao2; Wang, Yuanyuan2; Guo, Shengnan2; Jing, Fangyu2; Hu, Xiaodan2 |
| 刊名 | IUBMB LIFE
 |
| 出版日期 | 2016-10-01 |
| 卷号 | 68期号:10页码:817-822 |
| 关键词 | Breast Cancer Arginine Ornithine Diacspm Biomarker |
| ISSN号 | 1521-6543 |
| DOI | 10.1002/iub.1557 |
| 文献子类 | Article |
| 英文摘要 | Breast cancer (BC) is the most commonly diagnosed cancer in women worldwide. Arginine is a semiessential amino acid in humans and is essential for several biological pathways in malignant and normal cells, such as ornithine and N1, N12-diacetylspermine (DiAcSpm). This study aimed to determine the role of arginine and these downstream molecules in BC. Plasma arginine, ornithine, and arginine-to-ornithine ratio (AOR) were analysed by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Urine samples were measured by the colloid gold aggregation to test determination of urinary diAcSpm. A principal component analysis was performed to evaluate the results observed between breast tumor and control characteristics. Differences in individual metabolite concentrations between BC patients and controls were tested by receiver operating characteristics (ROC) analyses. Student's t tests were used to detect the differences between two groups of normally distributed variables, and Wilcoxon sign rank tests were performed for asymmetrically distributed variables. As we analyzed, BC patients had lower plasma arginine and arginine/ornithine level, and higher plasma ornithine and urinary DiAcSpm concentrations as compared with control patients (P = 0.028, 0.020, 0.002, and 0.011, respectively). And the ROC curve was drawn and the area under the curve of the metabolites was calculated to be 0.659 (P = 0.028), 0.645 (P = 0.045), 0.7233 (P = 0.002), 0.683 (P = 0.011), respectively. In addition, our analysis showed that arginine concentrations and AOR had a positive correlation with ER status, while ornithine had a negative correlation with T stage (P = 0.042, 0.083, 0.023, respectively). In conclusion, arginine and these downstream molecules were biomarkers for BC. More studies are needed to highlight the theoretical strengths. (C) 2016 IUBMB Life, 68(10):817-822, 2016 |
| WOS关键词 | CELL LUNG-CANCER ; TUMOR ; N-1,N-12-DIACETYLSPERMINE ; N-12-DIACETYLSPERMINE ; ADENOCARCINOMA ; CLASSIFICATION ; INVASIVENESS ; METABOLISM ; DISEASE ; URINE |
| WOS研究方向 | Biochemistry & Molecular Biology ; Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000388440500005 |
| 出版者 | WILEY-BLACKWELL |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/169760]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 通讯作者 | Zhu, Zhitu |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian, Peoples R China 2.Jinzhou Med Univ, Affiliated Hosp 1, Ctr Canc, 2 Fifth Sect Renmin St, Jinzhou 121000, Liaoning, Peoples R China 3.Runsheng Kangtai Biomed Technol Co Ltd, Jinzhou, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jing, Yu,Hu, Lu,Gao, Yu,et al. Identification of Arginine and Its "Downstream" Molecules as Potential Markers of Breast Cancer[J]. IUBMB LIFE,2016,68(10):817-822. |
| APA | Jing, Yu.,Hu, Lu.,Gao, Yu.,Cao, Yunfeng.,Zhang, Yinxu.,...&Zhu, Zhitu.(2016).Identification of Arginine and Its "Downstream" Molecules as Potential Markers of Breast Cancer.IUBMB LIFE,68(10),817-822. |
| MLA | Jing, Yu,et al."Identification of Arginine and Its "Downstream" Molecules as Potential Markers of Breast Cancer".IUBMB LIFE 68.10(2016):817-822. |
入库方式： OAI收割
来源：大连化学物理研究所
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