Association of Plasma Arginine with Breast Cancer Molecular Subtypes in Women of Liaoning Province
文献类型：期刊论文
| 作者 | Jing, Fangyu2; Zhu, Zhitu2; Hu, Lu2; Gao, Yu2; Cao, Yunfeng1,3; Zhang, Yinxu2; Xu, Minghao2; Wang, Yuanyuan2; Jing, Yu2; Guo, Shengnan2 |
| 刊名 | IUBMB LIFE
 |
| 出版日期 | 2016-12-01 |
| 卷号 | 68期号:12页码:980-984 |
| 关键词 | Breast Cancer Arginine Molecular Subtypes Biomarkers |
| ISSN号 | 1521-6543 |
| DOI | 10.1002/iub.1581 |
| 文献子类 | Article |
| 英文摘要 | Arginine is one of the human nonessential amino acids critical for the growth of human cancers. The aim of this study is to investigate the variation of arginine between breast cancer (BC) patients and benign mammary gland disease (control) patients to determine its value in predicting the risk of BC. We also explore the associations between arginine levels and breast cancer subtypes. Preoperative blood samples were obtained from 267 patients (102 BC and 165 controls) in 2015. Plasma arginine values were determined for all preoperative blood samples using liquid chromatography-tandem mass spectrometry (LC-MS/MS) to analyse differences in arginine levels between BC patients and control patients and the correlations between arginine and clinicopathologic parameters in BC. The arginine levels of BC patients were significantly lower than those of control patients (5.96 [3.76-12.47] vs. 12.54 [7.14-24.94], P = 0.000). The area under the curve (AUC) for arginine was 0.721 (95% CI, 0.660-0.782, P<0.0001). The concentration of arginine was significantly different among different molecular BC subtypes (P = 0.030). Our results suggested that plasma arginine was associated with breast cancer molecular subtypes. (C) 2016 IUBMB Life, 68(12): 980-984, 2016 |
| WOS关键词 | METABOLOMICS ; IMPACT ; METABOLISM ; MARKERS ; BENIGN |
| WOS研究方向 | Biochemistry & Molecular Biology ; Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000388441600008 |
| 出版者 | WILEY-BLACKWELL |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/169766]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 通讯作者 | Zhu, Zhitu |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian, Peoples R China 2.Jinzhou Med Univ, Affiliated Hosp 1, Ctr Canc, 2,Fifth Sect Renmin St, Jinzhou 121000, Liaoning, Peoples R China 3.Runsheng Kangtai Biomed Technol Co Ltd, Jinzhou, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jing, Fangyu,Zhu, Zhitu,Hu, Lu,et al. Association of Plasma Arginine with Breast Cancer Molecular Subtypes in Women of Liaoning Province[J]. IUBMB LIFE,2016,68(12):980-984. |
| APA | Jing, Fangyu.,Zhu, Zhitu.,Hu, Lu.,Gao, Yu.,Cao, Yunfeng.,...&Hu, Xiaodan.(2016).Association of Plasma Arginine with Breast Cancer Molecular Subtypes in Women of Liaoning Province.IUBMB LIFE,68(12),980-984. |
| MLA | Jing, Fangyu,et al."Association of Plasma Arginine with Breast Cancer Molecular Subtypes in Women of Liaoning Province".IUBMB LIFE 68.12(2016):980-984. |
入库方式： OAI收割
来源：大连化学物理研究所
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