A dynamic in vivo-like organotypic blood-brain barrier model to probe metastatic brain tumors
文献类型：期刊论文
| 作者 | Zhang, Min1; Zhuang, Zhengping3; Qin, Jianhua1; Xu, Hui1,2; Li, Zhongyu1,2; Yu, Yue1,2; Sizdahkhani, Saman3; Ho, Winson S.3; Yin, Fangchao1,2; Wang, Li1 |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2016-11-10 |
| 卷号 | 6 |
| ISSN号 | 2045-2322 |
| DOI | 10.1038/srep36670 |
| 文献子类 | Article |
| 英文摘要 | The blood-brain barrier (BBB) restricts the uptake of many neuro-therapeutic molecules, presenting a formidable hurdle to drug development in brain diseases. We proposed a new and dynamic in vivo-like three-dimensional microfluidic system that replicates the key structural, functional and mechanical properties of the blood-brain barrier in vivo. Multiple factors in this system work synergistically to accentuate BBB-specific attributes-permitting the analysis of complex organ-level responses in both normal and pathological microenvironments in brain tumors. The complex BBB microenvironment is reproduced in this system via physical cell-cell interaction, vascular mechanical cues and cell migration. This model possesses the unique capability to examine brain metastasis of human lung, breast and melanoma cells and their therapeutic responses to chemotherapy. The results suggest that the interactions between cancer cells and astrocytes in BBB microenvironment might affect the ability of malignant brain tumors to traverse between brain and vascular compartments. Furthermore, quantification of spatially resolved barrier functions exists within a single assay, providing a versatile and valuable platform for pharmaceutical development, drug testing and neuroscientific research. |
| WOS关键词 | MICROVASCULAR ENDOTHELIAL-CELLS ; VITRO MODEL ; ELECTRICAL-RESISTANCE ; BBB ; CANCER ; CHIP ; RAT ; PERMEABILITY ; EXPRESSION ; SYSTEM |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000387510800001 |
| 出版者 | NATURE PUBLISHING GROUP |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/169826]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 通讯作者 | Qin, Jianhua |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Div Biotechnol, Dalian, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.NINDS, Surg Neurol Branch, NIH, Bldg 36,Rm 4D04, Bethesda, MD 20892 USA |
| 推荐引用方式 GB/T 7714 | Zhang, Min,Zhuang, Zhengping,Qin, Jianhua,et al. A dynamic in vivo-like organotypic blood-brain barrier model to probe metastatic brain tumors[J]. SCIENTIFIC REPORTS,2016,6. |
| APA | Zhang, Min.,Zhuang, Zhengping.,Qin, Jianhua.,Xu, Hui.,Li, Zhongyu.,...&Jiang, Lei.(2016).A dynamic in vivo-like organotypic blood-brain barrier model to probe metastatic brain tumors.SCIENTIFIC REPORTS,6. |
| MLA | Zhang, Min,et al."A dynamic in vivo-like organotypic blood-brain barrier model to probe metastatic brain tumors".SCIENTIFIC REPORTS 6(2016). |
入库方式： OAI收割
来源：大连化学物理研究所
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