Synthesis and evaluation of sulfobetaine zwitterionic polymer bonded stationary phase
文献类型：期刊论文
| 作者 | Shen, Aijin1; Yan, Jingyu1; Dong, Xuefang1,2; Long, Zhen3; Jin, Gaowa1; Liang, Lina3; Liang, Xinmiao1,4; Yu, Dongping1,2; Guo, Zhimou1,4 |
| 刊名 | TALANTA
 |
| 出版日期 | 2016-12-01 |
| 卷号 | 161页码:860-866 |
| 关键词 | Hydrophilic Interaction Chromatography Sulfobetaine Zwitterionic Stationary Phase Reversible Addition-fragmentation Transfer Polymerization Saccharide Separation |
| ISSN号 | 0039-9140 |
| DOI | 10.1016/j.talanta.2016.09.003 |
| 文献子类 | Article |
| 英文摘要 | Zwitterionic polymer stationary phases have attracted increasing attention in hydrophilic interaction chromatography (HILIC). In this work, a zwitterionic sulfobetaine functionalized polyacrylamide stationary phase (named TENS) based on porous silica particles was prepared via controlled surface initiated reversible addition fragmentation transfer (RAFT) polymerization. Instead of traditional methacrylate type sulfobetaine monomer, acrylamide type sulfobetaine monomer, which has higher chemical stability and hydrophicility, was employed in this work. The characterization of elemental analysis and solid-state C-13 cross polarization/magic-anglespinning nuclear magnetic resonance indicated the successful preparation of TENS stationary phase. Meanwhile, scanning electron microscope (SEM), nitrogen adsorption experiment and study of size exclusion performance were conducted, revealing that the surface initiated polymerization was well controlled. For better understanding of TENS material under HILIC mode, chromatographic evaluation of TENS material was performed, among which, TENS material exhibited good hydrophilicity and chemical stability. To further study the applicability of TENS material, saccharides which were considered as challenging targets in HILIC, were chosen as tested analytes. Various saccharide samples, including fructooligosaccharide, trisaccharide isomers and ginsenosides, were well separated on TENS material. Moreover, TENS material displayed good selectivity for the enrichment of glycopeptides. These results demonstrated the capability of TENS as a promising material in glycomics and glycoproteomics. |
| WOS关键词 | INTERACTION LIQUID-CHROMATOGRAPHY ; HYDROPHILIC INTERACTION CHROMATOGRAPHY ; TANDEM MASS-SPECTROMETRY ; MONOCLONAL-ANTIBODIES ; BREAST-CANCER ; SEPARATION ; SILICA ; MODE ; FOOD |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000386989500114 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/169842]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 通讯作者 | Liang, Xinmiao; Guo, Zhimou |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Thermofisher Sci Corp, Beijing 100080, Peoples R China 4.Nantong Univ, Coinnovat Ctr Neuroregenerat, Nantong 226019, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shen, Aijin,Yan, Jingyu,Dong, Xuefang,et al. Synthesis and evaluation of sulfobetaine zwitterionic polymer bonded stationary phase[J]. TALANTA,2016,161:860-866. |
| APA | Shen, Aijin.,Yan, Jingyu.,Dong, Xuefang.,Long, Zhen.,Jin, Gaowa.,...&Guo, Zhimou.(2016).Synthesis and evaluation of sulfobetaine zwitterionic polymer bonded stationary phase.TALANTA,161,860-866. |
| MLA | Shen, Aijin,et al."Synthesis and evaluation of sulfobetaine zwitterionic polymer bonded stationary phase".TALANTA 161(2016):860-866. |
入库方式： OAI收割
来源：大连化学物理研究所
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