Degradation prediction model and stem cell growth of gelatin-PEG composite hydrogel
文献类型：期刊论文
| 作者 | Lv, Shijie4; Qiao, Qinglong2; Zhang, Rui5; Xiao, Jing3; Sun, Guangwei2; Liu, Yang2; Zhou, Nan2,3; Liu, Chang1,2; Sun, Dongsheng2 |
| 刊名 | JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
 |
| 出版日期 | 2016-12-01 |
| 卷号 | 104期号:12页码:3149-3156 |
| 关键词 | Gelatin-peg Hydrogel Degradation Model Response Surface Methodology Stem Cells |
| ISSN号 | 1549-3296 |
| DOI | 10.1002/jbm.a.35847 |
| 文献子类 | Article |
| 英文摘要 | Gelatin hydrogel has great potential in regenerative medicine. The degradation of gelatin hydrogel is important to control the release profile of encapsulated biomolecules and regulate in vivo tissue repair process. As a plasticizer, PEG can significantly improve the mechanical property of gelatin hydrogel. However, how preparation parameters affect the degradation rate of gelatin-PEG composite hydrogel is still not clear. In this study, the significant effect factor, glutaraldehyde (GA) concentration, was confirmed by means of Plackett-Burman method. Then a mathematical model was built to predict the degradation rate of composite hydrogels under different preparation conditions using the response surface method (RSM), which was helpful to prepare the certain composite hydrogel with desired degradation rate. In addition, it was found that gelatin-PEG composite hydrogel surface well supported the adhesion and growth of human mesenchymal stem cells (MSCs). Moreover, PEG concentration not only could adjust hydrogel degradation more subtly, but also might increase the cross-linking degree and affect the cell migration. Therefore, these results would be useful to optimize the preparation of gelatin-PEG composite hydrogel for drug delivery or tissue engineering. (c) 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 3149-3156, 2016. |
| WOS关键词 | GLUTARALDEHYDE CROSS-LINKING ; CONTROLLED-RELEASE ; BONE REGENERATION ; DELIVERY-SYSTEMS ; SCAFFOLD ; FILMS |
| WOS研究方向 | Engineering ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000386932000022 |
| 出版者 | WILEY-BLACKWELL |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/169906]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 通讯作者 | Sun, Guangwei; Liu, Yang |
| 作者单位 | 1.Dalian Municipal Cent Hosp, Dalian 116033, Peoples R China 2.Chinese Acad Sci, Sci Res Ctr Translat Med, Dalian Inst Chem Phys, Dalian 116023, Peoples R China 3.Dalian Med Univ, Dept Oral Pathol, Coll Stomatol, Dalian 116044, Peoples R China 4.Dalian Matern & Child Healthcare Hosp, Dalian 116033, Peoples R China 5.Dalian Med Univ, Affiliated Hosp 1, Dept Stomatol, Dalian 116023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lv, Shijie,Qiao, Qinglong,Zhang, Rui,et al. Degradation prediction model and stem cell growth of gelatin-PEG composite hydrogel[J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,2016,104(12):3149-3156. |
| APA | Lv, Shijie.,Qiao, Qinglong.,Zhang, Rui.,Xiao, Jing.,Sun, Guangwei.,...&Sun, Dongsheng.(2016).Degradation prediction model and stem cell growth of gelatin-PEG composite hydrogel.JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,104(12),3149-3156. |
| MLA | Lv, Shijie,et al."Degradation prediction model and stem cell growth of gelatin-PEG composite hydrogel".JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A 104.12(2016):3149-3156. |
入库方式： OAI收割
来源：大连化学物理研究所
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