The Antinociceptive Properties of the Corydalis yanhusuo Extract
文献类型：期刊论文
| 作者 | Civelli, Olivier1,4,5; Wang, Lien1; Zhang, Yan1,6; Wang, Zhiwei1; Gong, Nian2; Kweon, Tae Dong2; Vo, Benjamin2; Wang, Chaoran3; Zhang, Xiuli3; Chung, Jae Yoon1,7 |
| 刊名 | PLOS ONE
 |
| 出版日期 | 2016-09-13 |
| 卷号 | 11期号:9 |
| ISSN号 | 1932-6203 |
| DOI | 10.1371/journal.pone.0162875 |
| 文献子类 | Article |
| 英文摘要 | Corydalis yanhusuo. W.T. extracts (YHS) are widely used for the treatment of pain and inflammation. There are a few studies that assessed the effects of YHS in pain assays; however, none of these studies has systematically compared its activities in the different pain animal modes namely: acute, inflammatory and chronic pain. Furthermore, little is known about the mechanism of YHS activity in these assays. The aim of this study was to systematically evaluate the antinociceptive properties of YHS by testing it in four standardized pain assays and to investigate its mechanism. YHS antinociceptive properties were analyzed in the tail flick, the formalin paw licking, the von Frey filament and the hot box assays after spinal nerve ligation, which monitors acute nociceptive, persistent inflammatory and chronic neuropathic pain, respectively. YHS pharmacological profile was determined by screening it against a battery of G-protein coupled receptors and its mechanism of action was studied using knock-out mice. Our study shows that YHS, at a non-sedative dose, increases the tail flick latency in the tail flick assay without resulting in development of tolerance. YHS also decreases paw licking time in the formalin assay. Further, YHS increases paw withdraw threshold and latency in the von Frey filament and the hot box assays, respectively. In vitro, YHS exhibits prominent dopamine receptor antagonistic properties. In dopamine D2 receptor knockout mice, its antinociceptive effects are attenuated in acute and neuropathic pain but not inflammatory pain assays. Our results therefore indicate that YHS effectively attenuates acute, inflammatory and neuropathic pain, without causing tolerance. The effects on acute and neuropathic pain, but not inflammatory pain, are at least partially mediated through dopamine D2 receptor antagonism. Since YHS is a dietary supplement commercially available in the United States, our data suggest that it might be a candidate for alternative pain treatment. |
| WOS关键词 | TRADITIONAL CHINESE MEDICINE ; DOPAMINE D2 RECEPTORS ; NEUROPATHIC PAIN ; FORMALIN TEST ; ISOQUINOLINE ALKALOIDS ; NUCLEUS-ACCUMBENS ; SCIATIC-NERVE ; RATS ; MICE ; STIMULATION |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000383681000065 |
| 出版者 | PUBLIC LIBRARY SCIENCE |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/169966]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 通讯作者 | Civelli, Olivier |
| 作者单位 | 1.Univ Calif Irvine, Dept Pharmacol, Irvine, CA 92717 USA 2.Univ Calif Irvine, Dept Anesthesiol & Perioperat Care, Irvine, CA USA 3.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian, Liaoning, Peoples R China 4.Univ Calif Irvine, Dept Pharmaceut Sci, Irvine, CA 92697 USA 5.Univ Calif Irvine, Dev & Cell Biol, Irvine, CA 92617 USA 6.Shanghai Jiao Tong Univ, Sch Pharm, Shanghai, Peoples R China 7.Wonkwang Univ, Dept Anesthesiol & Pain Med, Sanbon Hosp, Gunpo, Gyeonggi, South Korea |
| 推荐引用方式 GB/T 7714 | Civelli, Olivier,Wang, Lien,Zhang, Yan,et al. The Antinociceptive Properties of the Corydalis yanhusuo Extract[J]. PLOS ONE,2016,11(9). |
| APA | Civelli, Olivier.,Wang, Lien.,Zhang, Yan.,Wang, Zhiwei.,Gong, Nian.,...&Luo, David Z..(2016).The Antinociceptive Properties of the Corydalis yanhusuo Extract.PLOS ONE,11(9). |
| MLA | Civelli, Olivier,et al."The Antinociceptive Properties of the Corydalis yanhusuo Extract".PLOS ONE 11.9(2016). |
入库方式： OAI收割
来源：大连化学物理研究所
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