Nontargeted Screening Method for Illegal Additives Based on Ultrahigh-Performance Liquid Chromatography-High-Resolution Mass Spectrometry
文献类型：期刊论文
| 作者 | Kong, Hongwei1,2; Fu, Yanqing1,2; Zhou, Zhihui1,2; Lu, Xin1,2; Zhao, Xinjie1,2; Chen, Yihui3; Chen, Jia4; Wu, Zeming5; Xu, Zhiliang4; Zhao, Chunxia1,2 |
| 刊名 | ANALYTICAL CHEMISTRY
 |
| 出版日期 | 2016-09-06 |
| 卷号 | 88期号:17页码:8870-8877 |
| ISSN号 | 0003-2700 |
| DOI | 10.1021/acs.analchem.6b02482 |
| 文献子类 | Article |
| 英文摘要 | Identification of illegal additives in complex matrixes is important in the food safety field. In this study a nontargeted screening strategy was developed to find illegal additives based on ultrahigh-performance liquid chromatography-high-resolution mass spectrometry (UHPLC-HRMS). First, an analytical method for possible illegal additives in complex matrixes was established including fast sample pretreatment, accurate UHPLC separation, and HRMS detection. Second, efficient data processing and differential analysis workflow were suggested and applied to find potential risk compounds. Third, structure elucidation of risk compounds was performed by (1) searching online databases [Metlin and the Human Metabolome Database (HMDB)] and an in-house database which was established at the above-defined conditions of UHPLC-HRMS analysis and contains information on retention time, mass spectra (MS), and tandem mass spectra (MS/MS) of 475 illegal additives, (2) analyzing fragment ions, and (3) referring to fragmentation rules. Fish was taken as an example to show the usefulness of the nontargeted screening strategy, and six additives were found in suspected fish samples. Quantitative analysis was further carried out to determine the contents of these compounds. The satisfactory application of this strategy in fish samples means that it can also be used in the screening of illegal additives in other kinds of food samples. |
| WOS关键词 | MS-BASED METABOLOMICS ; MULTIRESIDUE ANALYSIS ; ORGANIC CONTAMINANTS ; ANTIBIOTIC-RESIDUES ; VETERINARY DRUGS ; QUECHERS METHOD ; LC-MS/MS ; FOOD ; ORBITRAP ; IDENTIFICATION |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000382805900073 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/170202]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 通讯作者 | Zhao, Chunxia; Xu, Guowang |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China 3.Xiangshan Entry Exit Inspect & Quarantine Bur, Ningbo 315000, Zhejiang, Peoples R China 4.Hangzhou Pooke Testing Technol Co Ltd, Hangzhou 310000, Zhejiang, Peoples R China 5.Thermo Fisher Sci, Applicat Ctr, Shanghai 210623, Peoples R China |
| 推荐引用方式 GB/T 7714 | Kong, Hongwei,Fu, Yanqing,Zhou, Zhihui,et al. Nontargeted Screening Method for Illegal Additives Based on Ultrahigh-Performance Liquid Chromatography-High-Resolution Mass Spectrometry[J]. ANALYTICAL CHEMISTRY,2016,88(17):8870-8877. |
| APA | Kong, Hongwei.,Fu, Yanqing.,Zhou, Zhihui.,Lu, Xin.,Zhao, Xinjie.,...&Xu, Guowang.(2016).Nontargeted Screening Method for Illegal Additives Based on Ultrahigh-Performance Liquid Chromatography-High-Resolution Mass Spectrometry.ANALYTICAL CHEMISTRY,88(17),8870-8877. |
| MLA | Kong, Hongwei,et al."Nontargeted Screening Method for Illegal Additives Based on Ultrahigh-Performance Liquid Chromatography-High-Resolution Mass Spectrometry".ANALYTICAL CHEMISTRY 88.17(2016):8870-8877. |
入库方式： OAI收割
来源：大连化学物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。