中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Formal Synthesis of Gracilamine Using Rh(I)-Catalyzed [3+2+1] Cycloaddition of 1-Yne-Vinylcyclopropanes and CO

文献类型:期刊论文

作者Bose, Sritama; Yang, Jun; Yu, Zhi-Xiang
刊名JOURNAL OF ORGANIC CHEMISTRY
出版日期2016-08-05
卷号81期号:15页码:6757-6765
ISSN号0022-3263
DOI10.1021/acs.joc.6b00608
文献子类Article
英文摘要Reported here is a formal synthesis of gracilamine using Rh(I)-catalyzed [3 + 2 + 1] reaction of yne-VCP (+/-)-4 and CO. The key reaction gave the cycloadduct (+/-)-trans-3 with the A-B-C core structure of gracilamine. This advanced intermediate was further transformed to Gao's intermediate (+/-)-2 via regular transformations to realize the formal synthesis of gracilamine. The present strategy was used to accomplish the asymmetric formal synthesis of gracilamine using chiral substrate (+)-4.
WOS关键词AROMATIC-ALDEHYDES ; AMARYLLIDACEAE ALKALOIDS ; SCELETIUM ALKALOIDS ; STEREOCENTERS ; ALKYNYLATION ; ADDITIONS
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000381236000062
出版者AMER CHEMICAL SOC
源URL[http://cas-ir.dicp.ac.cn/handle/321008/170304]  
专题大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者Yu, Zhi-Xiang
作者单位Peking Univ, Coll Chem, Key Lab Bioorgan Chem & Mol Engn, BNLMS,Minist Educ, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Bose, Sritama,Yang, Jun,Yu, Zhi-Xiang. Formal Synthesis of Gracilamine Using Rh(I)-Catalyzed [3+2+1] Cycloaddition of 1-Yne-Vinylcyclopropanes and CO[J]. JOURNAL OF ORGANIC CHEMISTRY,2016,81(15):6757-6765.
APA Bose, Sritama,Yang, Jun,&Yu, Zhi-Xiang.(2016).Formal Synthesis of Gracilamine Using Rh(I)-Catalyzed [3+2+1] Cycloaddition of 1-Yne-Vinylcyclopropanes and CO.JOURNAL OF ORGANIC CHEMISTRY,81(15),6757-6765.
MLA Bose, Sritama,et al."Formal Synthesis of Gracilamine Using Rh(I)-Catalyzed [3+2+1] Cycloaddition of 1-Yne-Vinylcyclopropanes and CO".JOURNAL OF ORGANIC CHEMISTRY 81.15(2016):6757-6765.

入库方式: OAI收割

来源:大连化学物理研究所

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