Synthesis of Chiral Piperazines via Hydrogenation of Pyrazines Activated by Alkyl Halides
文献类型：期刊论文
| 作者 | Wang, Baomin2; Huang, Wen-Xue1,2; Liu, Lian-Jin1; Wu, Bo1; Feng, Guang-Shou1; Zhou, Yong-Gui1 |
| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2016-07-01 |
| 卷号 | 18期号:13页码:3082-3085 |
| ISSN号 | 1523-7060 |
| DOI | 10.1021/acs.orglett.6b01190 |
| 文献子类 | Article |
| 英文摘要 | A facile method has been developed for the synthesis of chiral piperazines through Ir-catalyzed hydrogenation of pyrazines activated by alkyl halides, giving a wide range of chiral piperazines including 3-substituted as well as 2,3- and 3,5-disubstituted ones with up to 96% ee. The high enantioselectivity, easy scalability, and concise drug synthesis demonstrate the practical utility. |
| WOS关键词 | CATALYZED ASYMMETRIC HYDROGENATION ; NK1 RECEPTOR ANTAGONIST ; HIV PROTEASE INHIBITOR ; ENANTIOSELECTIVE REDUCTION ; HETEROAROMATIC-COMPOUNDS ; ISOQUINOLINIUM SALTS ; PYRIDINIUM SALTS ; QUINOLINES ; QUINOXALINES ; DERIVATIVES |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000379455300011 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/170364]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 通讯作者 | Zhou, Yong-Gui |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, 457 Zhongshan Rd, Dalian 116023, Peoples R China 2.Dalian Univ Technol, Sch Pharmaceut Sci & Technol, State Key Lab Fine Chem, 2 Linggong Rd, Dalian 116024, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Baomin,Huang, Wen-Xue,Liu, Lian-Jin,et al. Synthesis of Chiral Piperazines via Hydrogenation of Pyrazines Activated by Alkyl Halides[J]. ORGANIC LETTERS,2016,18(13):3082-3085. |
| APA | Wang, Baomin,Huang, Wen-Xue,Liu, Lian-Jin,Wu, Bo,Feng, Guang-Shou,&Zhou, Yong-Gui.(2016).Synthesis of Chiral Piperazines via Hydrogenation of Pyrazines Activated by Alkyl Halides.ORGANIC LETTERS,18(13),3082-3085. |
| MLA | Wang, Baomin,et al."Synthesis of Chiral Piperazines via Hydrogenation of Pyrazines Activated by Alkyl Halides".ORGANIC LETTERS 18.13(2016):3082-3085. |
入库方式： OAI收割
来源：大连化学物理研究所
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