Small-Protein-Stabilized Semiconductor Nanoprobe for Targeted Imaging of Cancer Cells
文献类型：期刊论文
| 作者 | Jiang, Qike3; Lan, Tian1; Cheng, Zhen2; Zhao, Ning1; Liu, Hongguang1; Liu, Siyu1 |
| 刊名 | CHEMBIOCHEM
 |
| 出版日期 | 2016-07-01 |
| 卷号 | 17期号:13页码:1202-1206 |
| 关键词 | Affibody Her2 Fluorescent Imaging One-pot Synthesis Quantum Dots |
| ISSN号 | 1439-4227 |
| DOI | 10.1002/cbic.201600219 |
| 文献子类 | Article |
| 英文摘要 | Recently, semiconductor nanoparticles such as quantum dots (QDs) have attracted significant attention for bioimaging. Complex chemical functionalization, surface modification, and bioconjugation chemistry are generally required to tag biomolecules to QDs for imaging of different biomarkers. In this study, we report a simple method for production of QDs stabilized by the small protein, Affibody (AF-QDs) for fluorescent imaging of the human epidermal growth factor receptor type2 (HER2) in human A549 lung cancer cells. This one-pot synthesis of AF-QDs avoids complex chemical conjugation procedures and demonstrates a promising approach for the preparation of fluorescent nanoprobes for imaging of cancer targets. |
| WOS关键词 | QUANTUM DOTS ; BREAST-CANCER ; ANTI-HER2 ANTIBODY ; IN-VIVO ; NANOPARTICLES ; TUMORS ; HER2 ; LUNG ; PET |
| WOS研究方向 | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000379826400003 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/170366]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 通讯作者 | Cheng, Zhen; Liu, Hongguang |
| 作者单位 | 1.Northeastern Univ, Inst Mol Med, Coll Life & Hlth Sci, 195 Chuangxin Rd, Shenyang 110000, Japan 2.Stanford Univ, Dept Radiol, Mol Imaging Program Stanford, 1201 Welch Rd, Stanford, CA 94040 USA 3.Chinese Acad Sci, Dalian Inst Chem Phys, 457 Zhongshan Rd, Dalian 116023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jiang, Qike,Lan, Tian,Cheng, Zhen,et al. Small-Protein-Stabilized Semiconductor Nanoprobe for Targeted Imaging of Cancer Cells[J]. CHEMBIOCHEM,2016,17(13):1202-1206. |
| APA | Jiang, Qike,Lan, Tian,Cheng, Zhen,Zhao, Ning,Liu, Hongguang,&Liu, Siyu.(2016).Small-Protein-Stabilized Semiconductor Nanoprobe for Targeted Imaging of Cancer Cells.CHEMBIOCHEM,17(13),1202-1206. |
| MLA | Jiang, Qike,et al."Small-Protein-Stabilized Semiconductor Nanoprobe for Targeted Imaging of Cancer Cells".CHEMBIOCHEM 17.13(2016):1202-1206. |
入库方式： OAI收割
来源：大连化学物理研究所
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