Irinotecan (CPT-11)-induced elevation of bile acids potentiates suppression of IL-10 expression
文献类型：期刊论文
| 作者 | Fang, Zhong-Ze1,2,3,4; Zhang, Dunfang5; Cao, Yun-Feng3,4; Xie, Cen1; Lu, Dan6; Sun, Dong-Xue1; Tanaka, Naoki1; Jiang, Changtao1; Chen, Qianming5; Chen, Yu5 |
| 刊名 | TOXICOLOGY AND APPLIED PHARMACOLOGY
 |
| 出版日期 | 2016-01-15 |
| 卷号 | 291页码:21-27 |
| 关键词 | Irinotecan (Cpt-11) Metabolomics Bile Acids Interleukin-10 |
| ISSN号 | 0041-008X |
| DOI | 10.1016/j.laap.2015.12.003 |
| 文献子类 | Article |
| 英文摘要 | Irinotecan (CPT-11) is a first-line anti-colon cancer drug, however; CPT-11-induced toxicity remains a key factor limiting its clinical application. To search for clues to the mechanism of CPT-11-induced toxicity, metabolomics was applied using ultra-performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight mass spectrometry. Intraperitoneal injection of 50 mg/kg of CPT-11 induced loss of body weight, and intestine toxicity. Changes in gallbladder morphology suggested alterations in bile acid metabolism, as revealed at the molecular level by analysis of the liver, bile, and ileum metabolomes between the vehicle treated control group and the CPT-11-treated group. Analysis of immune cell populations further showed that CPT-11 treatment significantly decreased the IL-10-producing CD4 T cell frequency in intestinal lamina propria lymphocytes, but not in spleen or mesenteric lymph nodes. In vitro cell culture studies showed that the addition of bile acids deoxycholic acid and taurodeoxycholic acid accelerated the CPT-11-induced suppression of IL-10 secretion by activated CD4(+) naive T cells isolated from mouse splenocytes. These results showed that CPT-11 treatment caused metabolic changes in the composition of bile acids that altered CPT-11-induced suppression of IL-10 expression. Published by Elsevier Inc. |
| WOS关键词 | INTESTINAL MUCOSITIS ; INDUCED COLITIS ; MICE ; CHEMOTHERAPY ; GLUCURONIDATION ; HEPATOTOXICITY ; INHIBITION ; METABOLISM ; TOXICITY ; PROTECTS |
| WOS研究方向 | Pharmacology & Pharmacy ; Toxicology |
| 语种 | 英语 |
| WOS记录号 | WOS:000378100100003 |
| 出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/170524]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 通讯作者 | Gonzalez, Frank J. |
| 作者单位 | 1.NCI, Lab Metab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA 2.Tianjin Med Univ, Sch Publ Hlth, Dept Toxicol, Tianjin, Peoples R China 3.Chinese Acad Sci, Dalian Inst Chem Phys, Joint Ctr Translat Med, Dalian, Peoples R China 4.Liaoning Med Univ, Affiliated Hosp 1, Dalian, Peoples R China 5.Sichuan Univ, State Key Lab Oral Dis, West China Hosp Stomatol, Chengdu 610064, Peoples R China 6.Tianjin Med Univ, Dept Immunol, Tianjin Key Lab Cellular & Mol Immunol, Tianjin, Peoples R China 7.Shandong Univ, Sch Pharmaceut Sci, Jinan 250100, Peoples R China |
| 推荐引用方式 GB/T 7714 | Fang, Zhong-Ze,Zhang, Dunfang,Cao, Yun-Feng,et al. Irinotecan (CPT-11)-induced elevation of bile acids potentiates suppression of IL-10 expression[J]. TOXICOLOGY AND APPLIED PHARMACOLOGY,2016,291:21-27. |
| APA | Fang, Zhong-Ze.,Zhang, Dunfang.,Cao, Yun-Feng.,Xie, Cen.,Lu, Dan.,...&Gonzalez, Frank J..(2016).Irinotecan (CPT-11)-induced elevation of bile acids potentiates suppression of IL-10 expression.TOXICOLOGY AND APPLIED PHARMACOLOGY,291,21-27. |
| MLA | Fang, Zhong-Ze,et al."Irinotecan (CPT-11)-induced elevation of bile acids potentiates suppression of IL-10 expression".TOXICOLOGY AND APPLIED PHARMACOLOGY 291(2016):21-27. |
入库方式： OAI收割
来源：大连化学物理研究所
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