A dielectric barrier discharge ionization based interface for online coupling surface plasmon resonance with mass spectrometry
文献类型：期刊论文
| 作者 | Zhang, Yiding1; Xu, Shuting1; Wen, Luhong2; Bai, Yu1; Niu, Li3; Song, Daqian4; Liu, Huwei1 |
| 刊名 | ANALYST
 |
| 出版日期 | 2016 |
| 卷号 | 141期号:11页码:3343-3348 |
| ISSN号 | 0003-2654 |
| DOI | 10.1039/c6an00561f |
| 文献子类 | Article |
| 英文摘要 | The online combination of surface plasmon resonance (SPR) with mass spectrometry (MS) could be beneficial for accurately acquiring molecular interaction data simultaneously with their structural information at high throughputs. In this work, a novel SPR-MS interface was developed using a dielectric barrier discharge ionization (DBDI) source. The DBDI source was placed in front of the MS inlet, generating an ionization plasma jet. A spray tip was set between the DBDI source outlet and the MS inlet, nebulizing the SPR sample solution. Using this interface, samples could first be studied by SPR, then sprayed and ionized, finally analyzed by MS. By analyzing model samples containing small-molecule drugs dissolved in salt containing solutions, the practicability of this SPR-DBDI-MS interface was proved, observing the consistent change of SPR and MS signals. Compared with our previously developed direct analysis in real time (DART) based SPR-MS interface, this new interface exhibited a higher and better tolerance to non-volatile salts, and different ionization capabilities for various samples. These results indicated that the interface could find further utilization in SPR-MS studies especially when physiological conditions were needed. |
| WOS关键词 | SERUM-ALBUMIN BINDERS ; ELECTROSPRAY-IONIZATION ; RECENT PROGRESS ; MS/MS SYSTEM ; ION-SOURCE ; PERFORMANCE ; BIOSENSOR ; SAMPLING/IONIZATION ; QUANTIFICATION ; IDENTIFICATION |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000377225600024 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/170602]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 通讯作者 | Bai, Yu; Liu, Huwei |
| 作者单位 | 1.Peking Univ, Beijing Natl Lab Mol Sci, Key Lab Bioorgan Chem & Mol Engn, Inst Analyt Chem,Coll Chem & Mol Engn,Minist Educ, Beijing 100871, Peoples R China 2.Ningbo Univ, Res Inst Adv Technol, Ningbo 315211, Zhejiang, Peoples R China 3.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Electroanalyt Chem, Changchun 130022, Jilin, Peoples R China 4.Jilin Univ, Coll Chem, Changchun 130012, Jilin, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Yiding,Xu, Shuting,Wen, Luhong,et al. A dielectric barrier discharge ionization based interface for online coupling surface plasmon resonance with mass spectrometry[J]. ANALYST,2016,141(11):3343-3348. |
| APA | Zhang, Yiding.,Xu, Shuting.,Wen, Luhong.,Bai, Yu.,Niu, Li.,...&Liu, Huwei.(2016).A dielectric barrier discharge ionization based interface for online coupling surface plasmon resonance with mass spectrometry.ANALYST,141(11),3343-3348. |
| MLA | Zhang, Yiding,et al."A dielectric barrier discharge ionization based interface for online coupling surface plasmon resonance with mass spectrometry".ANALYST 141.11(2016):3343-3348. |
入库方式： OAI收割
来源：大连化学物理研究所
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