Metabolomics Study of Roux-en-Y Gastric Bypass Surgery (RYGB) to Treat Type 2 Diabetes Patients Based on Ultraperformance Liquid Chromatography-Mass Spectrometry
文献类型：期刊论文
| 作者 | Luo, Ping1; Yu, Haoyong2; Zhao, Xinjie1; Bao, Yuqian2; Hong, Christopher S.3; Zhang, Pin4; Tu, Yinfang2; Yin, Peiyuan1; Gao, Peng1; Wei, Li2 |
| 刊名 | JOURNAL OF PROTEOME RESEARCH
 |
| 出版日期 | 2016-04-01 |
| 卷号 | 15期号:4页码:1288-1299 |
| 关键词 | Metabolomics Metabolic Profiling Roux-en-y Gastric Bypass Rygb Diabetes |
| ISSN号 | 1535-3893 |
| DOI | 10.1021/acs.jproteome.6b00022 |
| 文献子类 | Article |
| 英文摘要 | Roux-en-Y gastric bypass (RYGB) is one of the most effective treatments for long-term weight loss and diabetes remission; however, the mechanisms underlying these changes are not clearly understood. In this study, the serum metabolic profiles of 23 remission and 12 nonremission patients with type 2 diabetes mellitus (T2DM) were measured at baseline, 6- and 12-months after RYGB. A metabolomics analysis was performed based on ultra-performance liquid chromatography mass spectrometry. Clinical improvements in insulin sensitivity, energy metabolism, and inflammation were related to metabolic alterations of free fatty acids (FFAs), acylcarnitines, amino acids, bile acids, and lipids species. Differential metabolic profiles were observed between the two T2DM subgroups, and patients with severity fat accumulation and oxidation stress may be more suitable for RYGB. Baseline levels of tryptophan, bilirubin, and indoxyl sulfate measured prior to surgery as well as levels of FFA 16:0, FFA 18:3, FFA 17:2, and hippuric acid measured at 6 months after surgery best predicted the suitability and efficacy of RYGB for patients with T2DM. These metabolites represent potential biomarkers that may be clinically helpful in individualized treatment for T2DM patients by RYGB. |
| WOS关键词 | STEAROYL-COA DESATURASE ; CHAIN AMINO-ACIDS ; INSULIN-RESISTANCE ; BARIATRIC SURGERY ; SKELETAL-MUSCLE ; SERUM METABOLOMICS ; BETA-OXIDATION ; OBESE-PATIENTS ; BILE-ACIDS ; INFLAMMATION |
| WOS研究方向 | Biochemistry & Molecular Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000373519900018 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/170684]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 通讯作者 | Jia, Weiping; Xu, Guowang |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, 457 Zhongshan Rd, Dalian 116023, Peoples R China 2.Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Shanghai Key Lab Diabet Mellitus,Shanghai Diabet, Dept Endocrinol & Metab,Shanghai Clin Ctr Diabet, Yishan Rd 600, Shanghai 200233, Peoples R China 3.NINDS, NIH, Surg Neurol Branch, Bethesda, MD 20892 USA 4.Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Dept Gen Surg, Yishan Rd, Shanghai 200233, Peoples R China |
| 推荐引用方式 GB/T 7714 | Luo, Ping,Yu, Haoyong,Zhao, Xinjie,et al. Metabolomics Study of Roux-en-Y Gastric Bypass Surgery (RYGB) to Treat Type 2 Diabetes Patients Based on Ultraperformance Liquid Chromatography-Mass Spectrometry[J]. JOURNAL OF PROTEOME RESEARCH,2016,15(4):1288-1299. |
| APA | Luo, Ping.,Yu, Haoyong.,Zhao, Xinjie.,Bao, Yuqian.,Hong, Christopher S..,...&Xu, Guowang.(2016).Metabolomics Study of Roux-en-Y Gastric Bypass Surgery (RYGB) to Treat Type 2 Diabetes Patients Based on Ultraperformance Liquid Chromatography-Mass Spectrometry.JOURNAL OF PROTEOME RESEARCH,15(4),1288-1299. |
| MLA | Luo, Ping,et al."Metabolomics Study of Roux-en-Y Gastric Bypass Surgery (RYGB) to Treat Type 2 Diabetes Patients Based on Ultraperformance Liquid Chromatography-Mass Spectrometry".JOURNAL OF PROTEOME RESEARCH 15.4(2016):1288-1299. |
入库方式： OAI收割
来源：大连化学物理研究所
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