Acute nephrotoxicity of aristolochic acid in vitro: metabolomics study for intracellular metabolic time-course changes
文献类型：期刊论文
| 作者 | Liu, Xiaoyan1,2; Liu, Yanqiu3; Cheng, Mengchun1; Xiao, Hongbin4 |
| 刊名 | BIOMARKERS
 |
| 出版日期 | 2016-04-02 |
| 卷号 | 21期号:3页码:233-242 |
| 关键词 | Aristolochic Acid Nephrotoxicity Biomarker Hk-2 Metabolomics Uplc-ms |
| ISSN号 | 1354-750X |
| DOI | 10.3109/1354750X.2015.1134660 |
| 文献子类 | Article |
| 英文摘要 | Time-course metabolic changes of aristolochic acid nephrotoxicity (AAN) was investigated using acute AAN HK-2 model. And the AAN-related biomarkers were selected. In the results, 11 potential identified biomarkers were selected and validated using multivariate method combined with time-course analysis. Several metabolic pathways, including vitamin metabolism, lipids acalytion, trytophan metabolism and protein degradation were found to be associated with AAN pathology. This research will provide a valuable reference for the discovery of more potential biomarkers of AAN progression in clinic. |
| WOS关键词 | LIQUID CHROMATOGRAPHY/MASS SPECTROMETRY ; CYTOSOLIC CA2+ LEVELS ; RENAL TUBULAR CELLS ; LYSOPHOSPHATIDIC ACID ; BIOMARKER DISCOVERY ; MASS-SPECTROMETRY ; MESANGIAL CELLS ; CHINESE HERBS ; RATS ; TOXICITY |
| WOS研究方向 | Biotechnology & Applied Microbiology ; Toxicology |
| 语种 | 英语 |
| WOS记录号 | WOS:000373392600007 |
| 出版者 | TAYLOR & FRANCIS LTD |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/170692]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 通讯作者 | Xiao, Hongbin |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian, Peoples R China 2.Univ Chinese Acad Sci, Grad Sch, Beijing, Peoples R China 3.Dalian Med Univ, Acad Integrat Med, Dalian, Peoples R China 4.Univ Chinese Med, Syst Anal & Innovat Drug Res Ctr, Beijing 100029, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Xiaoyan,Liu, Yanqiu,Cheng, Mengchun,et al. Acute nephrotoxicity of aristolochic acid in vitro: metabolomics study for intracellular metabolic time-course changes[J]. BIOMARKERS,2016,21(3):233-242. |
| APA | Liu, Xiaoyan,Liu, Yanqiu,Cheng, Mengchun,&Xiao, Hongbin.(2016).Acute nephrotoxicity of aristolochic acid in vitro: metabolomics study for intracellular metabolic time-course changes.BIOMARKERS,21(3),233-242. |
| MLA | Liu, Xiaoyan,et al."Acute nephrotoxicity of aristolochic acid in vitro: metabolomics study for intracellular metabolic time-course changes".BIOMARKERS 21.3(2016):233-242. |
入库方式： OAI收割
来源：大连化学物理研究所
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