Ultra-high performance liquid chromatography with linear ion trap-Orbitrap hybrid mass spectrometry combined with a systematic strategy based on fragment ions for the rapid separation and characterization of components in Stellera chamaejasme extracts
文献类型：期刊论文
| 作者 | Zhang, Xiaozhe1; Wang, Zhixin1; Qu, Yang1; Wang, Li1; Xiao, Hongbin2 |
| 刊名 | JOURNAL OF SEPARATION SCIENCE
 |
| 出版日期 | 2016-04-01 |
| 卷号 | 39期号:7页码:1379-1388 |
| 关键词 | Fragment Ions Linear Ion Trap-orbitrap Stellera Chamaejasme Traditional Chinese Medicine Ultra-high Performance Liquid Chromatography |
| ISSN号 | 1615-9306 |
| DOI | 10.1002/jssc.201500981 |
| 文献子类 | Article |
| 英文摘要 | Stellera chamaejasme, a famous toxic herb, has been used in traditional Chinese medicine to treat various diseases. For decades, increasing attention inmodern pharmacological studies has been drawn to S. chamaejasme because of its potential anti-tumor, anti-virus, and anti-fungus activities. However, due to the intrinsic complexity of chemical constitutes, hardly any investigations formed an overall recognition for the chemical profiles of this herb. In this study, a rapid and sensitive ultra-high performance liquid chromatography coupled with linear ion trap-Orbitrap mass spectrometry method was developed to characterize the chemical components of S. chamaejasme extracts. Based on optimized ultra-high performance liquid chromatography and mass spectrometry conditions and systematic fragment ions-based strategy, a total of 47 components including flavones, diterpenes, coumarins, and lignans were simultaneously detected and identified or tentatively identified for the first time. The MSn fragmentation patterns of all the characterized compounds in positive or negative electrospray ionization modes were also explored and summarized. These results provided essential data for further pharmacological research on S. chamaejasme. Moreover, the method was demonstrated to be an efficient tool for rapid qualitative analysis of secondary metabolites from natural resources. |
| WOS关键词 | DAPHNANE-TYPE DITERPENOIDS ; WIKSTROEMIA-RETUSA ; ROOTS ; IDENTIFICATION ; CONSTITUENTS ; L. ; COMPOUND |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000374029500022 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/170726]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 通讯作者 | Zhang, Xiaozhe |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian, Peoples R China 2.Beijing Univ Chinese Med, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Xiaozhe,Wang, Zhixin,Qu, Yang,et al. Ultra-high performance liquid chromatography with linear ion trap-Orbitrap hybrid mass spectrometry combined with a systematic strategy based on fragment ions for the rapid separation and characterization of components in Stellera chamaejasme extracts[J]. JOURNAL OF SEPARATION SCIENCE,2016,39(7):1379-1388. |
| APA | Zhang, Xiaozhe,Wang, Zhixin,Qu, Yang,Wang, Li,&Xiao, Hongbin.(2016).Ultra-high performance liquid chromatography with linear ion trap-Orbitrap hybrid mass spectrometry combined with a systematic strategy based on fragment ions for the rapid separation and characterization of components in Stellera chamaejasme extracts.JOURNAL OF SEPARATION SCIENCE,39(7),1379-1388. |
| MLA | Zhang, Xiaozhe,et al."Ultra-high performance liquid chromatography with linear ion trap-Orbitrap hybrid mass spectrometry combined with a systematic strategy based on fragment ions for the rapid separation and characterization of components in Stellera chamaejasme extracts".JOURNAL OF SEPARATION SCIENCE 39.7(2016):1379-1388. |
入库方式： OAI收割
来源：大连化学物理研究所
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