Quantitative MS analysis of therapeutic mAbs and their glycosylation for pharmacokinetics study
文献类型：期刊论文
| 作者 | Zhang, Zhang2; Zhang, Shen2; Hu, Lianghai1; Gu, Jingkai1; Cong, Yuting1,2 |
| 刊名 | PROTEOMICS CLINICAL APPLICATIONS
 |
| 出版日期 | 2016-04-01 |
| 卷号 | 10期号:4页码:303-314 |
| 关键词 | Mass Spectrometry Pharmacokinetics Proteomics Therapeutic Mab |
| ISSN号 | 1862-8346 |
| DOI | 10.1002/prca.201500098 |
| 文献子类 | Review |
| 英文摘要 | Therapeutic mAbs play an important role in the treatment of a wide range of diseases. Due to their complexity, comprehensive evaluation of their pharmacokinetics has yet to be fully achieved. It is crucial to develop sensitive, accurate, reliable, and reproducible methods for quantitation of mAbs in complex samples. In addition, it is also important to evaluate the PTMs which can affect their safety and/or effectiveness. MS-based methods provide an emerging approach for quantitation of proteins and their modification forms. In this review, we give a brief overview of quantification analysis of mAbs in complex biological samples and the characterization of N-glycosylation by biological MS. |
| WOS关键词 | TANDEM MASS-SPECTROMETRY ; MULTIPLEXED ABSOLUTE QUANTIFICATION ; CONCATENATED SIGNATURE PEPTIDES ; ORTHOGONAL ARRAY OPTIMIZATION ; HUMANIZED MONOCLONAL-ANTIBODY ; LINKED IMMUNOSORBENT-ASSAY ; SAMPLE PREPARATION METHOD ; LC-MS/MS ; IMMUNOGLOBULIN-G ; LIQUID-CHROMATOGRAPHY |
| WOS研究方向 | Biochemistry & Molecular Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000373947200002 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/170750]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 通讯作者 | Hu, Lianghai |
| 作者单位 | 1.Jilin Univ, Sch Life Sci, Res Ctr Drug Metab, Changchun 130012, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Natl Chromatog R&D Ctr, Dalian 116012, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Zhang,Zhang, Shen,Hu, Lianghai,et al. Quantitative MS analysis of therapeutic mAbs and their glycosylation for pharmacokinetics study[J]. PROTEOMICS CLINICAL APPLICATIONS,2016,10(4):303-314. |
| APA | Zhang, Zhang,Zhang, Shen,Hu, Lianghai,Gu, Jingkai,&Cong, Yuting.(2016).Quantitative MS analysis of therapeutic mAbs and their glycosylation for pharmacokinetics study.PROTEOMICS CLINICAL APPLICATIONS,10(4),303-314. |
| MLA | Zhang, Zhang,et al."Quantitative MS analysis of therapeutic mAbs and their glycosylation for pharmacokinetics study".PROTEOMICS CLINICAL APPLICATIONS 10.4(2016):303-314. |
入库方式： OAI收割
来源：大连化学物理研究所
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