Desilylation-Activated Propargylic Transformation: Enantioselective Copper-Catalyzed [3+2] Cycloaddition of Propargylic Esters with -Naphthol or Phenol Derivatives
文献类型：期刊论文
| 作者 | Xu, Jie1; Shao, Long1,2; Wang, Ya-Hui1; Zhang, De-Yang1,2; Hu, Xiang-Ping1 |
| 刊名 | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
 |
| 出版日期 | 2016-04-11 |
| 卷号 | 55期号:16页码:5014-5018 |
| 关键词 | Asymmetric Catalysis Cycloaddition Copper Heterocycles Reaction Mechanisms |
| ISSN号 | 1433-7851 |
| DOI | 10.1002/anie.201510793 |
| 文献子类 | Article |
| 英文摘要 | A copper-catalyzed asymmetric [3+2] cycloaddition of 3-trimethylsilylpropargylic esters with either -naphthols or electron-rich phenols has been realized and proceeds by a desilylation-activated process. Under the catalysis of Cu(OAc)(2)H2O in combination with a structurally optimized ketimine P,N,N-ligand, a wide range of optically active 1,2-dihydronaphtho[2,1-b]furans or 2,3-dihydrobenzofurans were obtained in good yields and with high enantioselectivities (up to 96% ee). This represents the first desilylation-activated catalytic asymmetric propargylic transformation. |
| WOS关键词 | ALKYNYL GROUP-TRANSFER ; SUBSTITUTION-REACTIONS ; COUPLING REACTIONS ; BETA-KETOESTERS ; ALCOHOLS ; AMINATION ; ALKYLATION ; ACETATES ; AMINES ; CU |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000374496100025 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/170762]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 通讯作者 | Hu, Xiang-Ping |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, 457 Zhongshan Rd, Dalian 116023, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Jie,Shao, Long,Wang, Ya-Hui,et al. Desilylation-Activated Propargylic Transformation: Enantioselective Copper-Catalyzed [3+2] Cycloaddition of Propargylic Esters with -Naphthol or Phenol Derivatives[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2016,55(16):5014-5018. |
| APA | Xu, Jie,Shao, Long,Wang, Ya-Hui,Zhang, De-Yang,&Hu, Xiang-Ping.(2016).Desilylation-Activated Propargylic Transformation: Enantioselective Copper-Catalyzed [3+2] Cycloaddition of Propargylic Esters with -Naphthol or Phenol Derivatives.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,55(16),5014-5018. |
| MLA | Xu, Jie,et al."Desilylation-Activated Propargylic Transformation: Enantioselective Copper-Catalyzed [3+2] Cycloaddition of Propargylic Esters with -Naphthol or Phenol Derivatives".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 55.16(2016):5014-5018. |
入库方式： OAI收割
来源：大连化学物理研究所
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