Synthesis of a stationary phase based on silica modified with branched octadecyl groups by Michael addition and photoinduced thiol-yne click chemistry for the separation of basic compounds
文献类型：期刊论文
| 作者 | Ji, Yongsheng1; Zhang, Zhang1,2; Zou, Hanfa1; Huang, Guang1,2,3; Ou, Junjie1; Wang, Hongwei1,2,3; Peng, Xiaojun3; Wan, Hao1 |
| 刊名 | JOURNAL OF SEPARATION SCIENCE
 |
| 出版日期 | 2016-04-01 |
| 卷号 | 39期号:8页码:1461-1470 |
| 关键词 | Basic Compounds High-performance Liquid Chromatography Michael Addition Stationary Phases Thiol-yne Click Chemistry |
| ISSN号 | 1615-9306 |
| DOI | 10.1002/jssc.201501403 |
| 文献子类 | Article |
| 英文摘要 | A novel silica-based stationary phase with branched octadecyl groups was prepared by the sequential employment of the Michael addition reaction and photoinduced thiol-yne click chemistry with 3-aminopropyl-functionalized silicamicrospheres as the initialmaterial. The resulting stationary phase denoted as SiO2-N(C18)(4) was characterized by elemental analysis, FTIR spectroscopy and Raman spectroscopy, demonstrating the existence of branched octadecyl groups in silicamicrospheres. The separations of benzene homologous compounds, acid compounds and amine analogues were conducted, demonstratingmixed-mode separation mechanism on SiO2-N(C18)(4). Baseline separation of basic drugs mixture was acquired with the mobile phase of acetonitrile/H2O (5%, v/v). SiO2-N(C18)(4) was further applied to separate Corydalis yanhusuo Wang water extracts, and more baseline separation peaks were obtained for SiO2-N(C18)(4) than those on Atlantis dC18 column. It can be expected that this new silica-based stationary phase will exhibit great potential in the analysis of basic compounds. |
| WOS关键词 | PERFORMANCE LIQUID-CHROMATOGRAPHY ; W. T. WANG ; DONOR-ACCEPTOR SYSTEMS ; AROMATIC INTERACTIONS ; BETA-CYCLODEXTRIN ; RETENTION ; ALKALOIDS ; PURIFICATION ; BEHAVIOR ; COLUMN |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000374773000008 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/170844]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 通讯作者 | Ou, Junjie |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Dalian Univ Technol, State Key Lab Fine Chem, Dalian, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ji, Yongsheng,Zhang, Zhang,Zou, Hanfa,et al. Synthesis of a stationary phase based on silica modified with branched octadecyl groups by Michael addition and photoinduced thiol-yne click chemistry for the separation of basic compounds[J]. JOURNAL OF SEPARATION SCIENCE,2016,39(8):1461-1470. |
| APA | Ji, Yongsheng.,Zhang, Zhang.,Zou, Hanfa.,Huang, Guang.,Ou, Junjie.,...&Wan, Hao.(2016).Synthesis of a stationary phase based on silica modified with branched octadecyl groups by Michael addition and photoinduced thiol-yne click chemistry for the separation of basic compounds.JOURNAL OF SEPARATION SCIENCE,39(8),1461-1470. |
| MLA | Ji, Yongsheng,et al."Synthesis of a stationary phase based on silica modified with branched octadecyl groups by Michael addition and photoinduced thiol-yne click chemistry for the separation of basic compounds".JOURNAL OF SEPARATION SCIENCE 39.8(2016):1461-1470. |
入库方式： OAI收割
来源：大连化学物理研究所
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